State Highway 322 or SH 322 is a Texas state highway that runs from Henderson north to Interstate 20 near Longview. This route was designated on October 30, 1939 from Henderson to the Rusk/Gregg County Line. On February 11, 1944, SH 322 extended north to SH 149. On September 14, 1944, SH 322 extended to the traffic circle northeast of Henderson. On June 1, 1967, SH 322 extended northward to I-20.
SH 322 begins at a junction with US 259 in Henderson. It heads northeast from this junction to an intersection with FM 850. The highway continues to the northeast to an intersection with FM 1249. Heading towards the north, the highway continues to a junction with FM 2011. The highway continues to the north to an intersection with FM 2204. It continues to the north to a junction with FM 349 in Lakeport. As the highway continues to the northeast, it intersects SH 149 in Lakeport. SH 320 and SH 149 begin to run concurrently to the north until they split in Longview. SH 322 reaches its northern terminus at I-20 in Longview. The roadway continues to the north as Loop 281.