Talk:Whipple's disease

question

Who is credited for discovering that Tropheryma whipplei causes Whipple's disease? ReasonableLogicalMan(Talk 20:32, 3 February 2008 (UTC)

PMID 1377787 seems to be the publication of relevance, although various groups were looking at bacterial rRNA prior to this result. JFW | T@lk 15:54, 4 February 2008 (UTC)

PMID 12672878 closes the circle: T. whipplei was detected in biopsies from Whipple's original 1907 patient! JFW | T@lk 15:58, 4 February 2008 (UTC)

Recent reviews

The most recent reviews on this condition are:

• doi:10.1016/S1473-3099(08)70042-2 - Lancet Infect Dis 2008
• doi:10.1097/MOG.0b013e3282f3f4f1 - Curr Opin Gastroenterol 2008
• doi:10.1056/NEJMra062477 - N Engl J Med 2007

Citing Didier Raoult at least once is going to be inevitable :-). JFW | T@lk 11:14, 14 November 2010 (UTC)

Primary source: immune reconstitution syndrome happens in about 10% and can be nasty: link. JFW | T@lk 22:42, 6 December 2010 (UTC)

Expanding and updating

Now that I've started updating this I might as well give the article a good work-over and hopefully turn it into a useful resource. I still need to retrieve the Fenollar 2007 NEJM review. So far I've made expansions based on Schneider 2008. I will not use Marth & Schneider (2008, Curr Opin Gastroenterol)

By sections:

•  Done Signs and symptoms (could still add percentages, but probably meaningless)
• Mechanism (expand from Schneider and NEJM)
• Diagnosis (need expansion)
• Treatment (ditto)
• Epidemiology (could add something about prognosis)
• History (could have more historical content still)

Further input from everyone much appreciated. JFW | T@lk 11:36, 15 November 2010 (UTC)

Treatment section is "correct but thin/wobbly." I may be able to work on appropriate WP:RSMED that address:

• IRIS PMID 21135294
• Study for the Initial treatment of Morbus Whipple SIMW PMID 19879276
• Abx choice with ref to different sites of tissue dz, or abx allergies
• PCR surveillance of CSF
• prognosis

FeatherPluma (talk) 01:10, 31 October 2011 (UTC)

Nice work FeatherPluma! As you can see above I made this article one of my projects, and then I got distracted, possibly by an FAC elsewhere. I'll see what I can do to help, but sadly very busy in meatspace. With regards to the articles you mentioned, please bear in mind that we should be cautious with primary sources. JFW | T@lk 11:45, 31 October 2011 (UTC)

Some inaccuracies, sources?

Looking through, there are some statements that seem inaccurate and some that are not properly sourced. Under the section "Diagnosis" - skin rashes are quoted as a clinical manifestation. I am not familiar with this as a symptom, and cannot find this in any source, including the one cited (a french article, there are many perfectly good English reviews to cite in an English encyclopedia...) I will now correct this. I will also post about any other corrections. Treatment is also out of date. — Preceding unsigned comment added by Ibenami (talk • contribs) 23:12, 17 July 2014

Hello Ibenami - I believe the rashes are mentioned in an old source. I agree that the article is in need of updating; I've listed some reviews above but I never got round to improving the article.

Feel free to fix whatever is necessary and let me know if you need a hand! JFW | T@lk 15:59, 23 July 2014 (UTC)

Review

doi:10.1016/S1473-3099(22)00128-1 JFW | T@lk 04:59, 23 September 2022 (UTC)