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TNFAIP3-interacting protein 1 is a protein that in humans is encoded by the TNIP1 gene.[5][6][7]

AliasesTNIP1, ABIN-1, NAF1, VAN, nip40-1, TNFAIP3 interacting protein 1
External IDsMGI: 1926194 HomoloGene: 31355 GeneCards: TNIP1
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for TNIP1
Genomic location for TNIP1
Band5q33.1Start151,029,945 bp[1]
End151,093,577 bp[1]
RNA expression pattern
PBB GE TNIP1 207196 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 5: 151.03 – 151.09 MbChr 11: 54.91 – 54.96 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse


Association with autoimmune diseasesEdit


TNIP1 has been shown to interact with TNFAIP3[13] and MAPK1.[14]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145901 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020400 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Fukushi M, Dixon J, Kimura T, Tsurutani N, Dixon MJ, Yamamoto N (Jan 1999). "Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression". FEBS Letters. 442 (1): 83–8. doi:10.1016/S0014-5793(98)01631-7. PMID 9923610.
  6. ^ Gupta K, Ott D, Hope TJ, Siliciano RF, Boeke JD (Dec 2000). "A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions". Journal of Virology. 74 (24): 11811–24. doi:10.1128/JVI.74.24.11811-11824.2000. PMC 112464. PMID 11090181.
  7. ^ "Entrez Gene: TNIP1 TNFAIP3 interacting protein 1".
  8. ^ Allanore Y, Saad M, Dieudé P, Avouac J, Distler JH, Amouyel P, et al. (Jul 2011). "Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis". PLoS Genetics. 7 (7): e1002091. doi:10.1371/journal.pgen.1002091. PMC 3131285. PMID 21750679.
  9. ^ Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, et al. (Feb 2009). "Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways". Nature Genetics. 41 (2): 199–204. doi:10.1038/ng.311. PMC 2745122. PMID 19169254.
  10. ^ Bowes J, Orozco G, Flynn E, Ho P, Brier R, Marzo-Ortega H, et al. (Sep 2011). "Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis". Annals of the Rheumatic Diseases. 70 (9): 1641–4. doi:10.1136/ard.2011.150102. PMC 3147229. PMID 21623003.
  11. ^ Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, et al. (Nov 2009). "A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus". Nature Genetics. 41 (11): 1228–33. doi:10.1038/ng.468. PMC 2925843. PMID 19838195.
  12. ^ Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, et al. (Nov 2009). "Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus". Nature Genetics. 41 (11): 1234–7. doi:10.1038/ng.472. PMID 19838193.
  13. ^ Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R (Jun 1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN". The Journal of Cell Biology. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. PMC 2133159. PMID 10385526.
  14. ^ Zhang S, Fukushi M, Hashimoto S, Gao C, Huang L, Fukuyo Y, Nakajima T, Amagasa T, Enomoto S, Koike K, Miura O, Yamamoto N, Tsuchida N (Sep 2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochemical and Biophysical Research Communications. 297 (1): 17–23. doi:10.1016/S0006-291X(02)02086-7. PMID 12220502.

Further readingEdit

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