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Tumor necrosis factor ligand superfamily member 18 is a protein that in humans is encoded by the TNFSF18 gene.[5][6][7]

Protein TNFSF18 PDB 2Q1M.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesTNFSF18, AITRL, GITRL, TL6, hGITRL, TNLG2A, tumor necrosis factor superfamily member 18, TNF superfamily member 18
External IDsOMIM: 603898 MGI: 2673064 HomoloGene: 3732 GeneCards: TNFSF18
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TNFSF18
Genomic location for TNFSF18
Band1q25.1Start173,039,960 bp[1]
End173,050,963 bp[1]
RNA expression pattern
PBB GE TNFSF18 221371 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 173.04 – 173.05 MbChr 1: 161.49 – 161.51 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120337 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066755 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kwon B, Yu KY, Ni J, Yu GL, Jang IK, Kim YJ, Xing L, Liu D, Wang SX, Kwon BS (Mar 1999). "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand". J Biol Chem. 274 (10): 6056–61. doi:10.1074/jbc.274.10.6056. PMID 10037686.
  6. ^ Gurney AL, Marsters SA, Huang RM, Pitti RM, Mark DT, Baldwin DT, Gray AM, Dowd AD, Brush AD, Heldens AD, Schow AD, Goddard AD, Wood WI, Baker KP, Godowski PJ, Ashkenazi A (Apr 1999). "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR". Curr Biol. 9 (4): 215–8. doi:10.1016/S0960-9822(99)80093-1. PMID 10074428.
  7. ^ a b "Entrez Gene: TNFSF18 tumor necrosis factor (ligand) superfamily, member 18".

Further readingEdit