TNFSF12-TNFSF13

Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human gene.

TNFSF12-TNFSF13
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4HT1
Identifiers
Aliases	TNFSF12-TNFSF13, TWE-PRIL, TNFSF12-TNFSF13 readthrough
External IDs	MGI: 3845075 HomoloGene: 123930 GeneCards: TNFSF12-TNFSF13
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.1 Start 7,549,099 bp End 7,561,601 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B3 Start 69,573,403 bp End 69,586,924 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood stromal cell of endometrium monocyte gastric mucosa subcutaneous adipose tissue right coronary artery renal cortex thoracic aorta bone marrow cells ascending aorta Top expressed in lung ovary quadriceps femoris muscle duodenum muscle tissue adrenal gland bone marrow white adipose tissue uterus colon More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity protein binding tumor necrosis factor receptor binding signaling receptor binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region perinuclear region of cytoplasm extracellular space Biological process cell differentiation positive regulation of endothelial cell proliferation positive regulation of protein catabolic process extrinsic apoptotic signaling pathway tumor necrosis factor-mediated signaling pathway positive regulation of angiogenesis multicellular organism development angiogenesis immune response apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway endothelial cell migration signal transduction apoptotic process regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 407977 619441 Ensembl ENSG00000248871 ENSMUSG00000018752 UniProt O43508 n/a RefSeq (mRNA) NM_172089 NM_001034097 NM_001034098 NM_001159503 RefSeq (protein) NP_003800 n/a Location (UCSC) Chr 17: 7.55 – 7.56 Mb Chr 11: 69.57 – 69.59 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the tumor necrosis factor superfamily (TNFSF). It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of the family member 12 fused to the C-terminal domain of the family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of the family member 13 at the cell surface. It stimulates cycling in T-lymphoma and B-lymphoma cell lines. The mRNA transcript is expressed and translated in primary T cells and monocytes.

Further reading

• Hahne M, Kataoka T, Schröter M, et al. (1998). "APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth". J. Exp. Med. 188 (6): 1185–90. doi:10.1084/jem.188.6.1185. PMC 2212534. PMID 9743536.
• Kelly K, Manos E, Jensen G, et al. (2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death". Cancer Res. 60 (4): 1021–7. PMID 10706119.
• Wu Y, Bressette D, Carrell JA, et al. (2001). "Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS". J. Biol. Chem. 275 (45): 35478–85. doi:10.1074/jbc.M005224200. PMID 10956646.
• Yu G, Boone T, Delaney J, et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity". Nat. Immunol. 1 (3): 252–6. doi:10.1038/79802. PMID 10973284. S2CID 6799584.
• López-Fraga M, Fernández R, Albar JP, Hahne M (2002). "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase". EMBO Rep. 2 (10): 945–51. doi:10.1093/embo-reports/kve198. PMC 1084076. PMID 11571266.
• Roschke V, Sosnovtseva S, Ward CD, et al. (2002). "BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases". J. Immunol. 169 (8): 4314–21. doi:10.4049/jimmunol.169.8.4314. PMID 12370363.
• Pradet-Balade B, Medema JP, López-Fraga M, et al. (2002). "An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK–APRIL fusion protein". EMBO J. 21 (21): 5711–20. doi:10.1093/emboj/cdf565. PMC 131062. PMID 12411489.
• Hendriks J, Planelles L, de Jong-Odding J, et al. (2005). "Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation". Cell Death Differ. 12 (6): 637–48. doi:10.1038/sj.cdd.4401647. PMID 15846369.