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The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000008952 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027706 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Daimon M, Susa S, Suzuki K, Kato T, Yamatani K, Sasaki H (Feb 1997). "Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp1)". Biochem Biophys Res Commun. 230 (1): 100–4. doi:10.1006/bbrc.1996.5892. PMID 9020021.
  6. ^ Meyer HA, Grau H, Kraft R, Kostka S, Prehn S, Kalies KU, Hartmann E (Jun 2000). "Mammalian Sec61 is associated with Sec62 and Sec63". J Biol Chem. 275 (19): 14550–7. doi:10.1074/jbc.275.19.14550. PMID 10799540.
  7. ^ a b "Entrez Gene: TLOC1 translocation protein 1".

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