Telomeric repeat-binding factor 2-interacting protein 1 also known as repressor activator protein 1 (Rap1) is a protein that in humans is encoded by the TERF2IP gene.[5][6]

TERF2IP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTERF2IP, DRIP5, RAP1, TERF2 interacting protein
External IDsOMIM: 605061 MGI: 1929871 HomoloGene: 10357 GeneCards: TERF2IP
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018975

NM_020584

RefSeq (protein)

NP_061848

NP_065609

Location (UCSC)Chr 16: 75.65 – 75.76 MbChr 8: 112.74 – 112.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

TERF2IP has been shown to interact with Ku80,[7] Rad50[7] and TERF2.[5][7][8] Upon interaction, TERF2IP/TERF2 complex has been shown to bind to telomeric junction sites with higher affinity[9]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166848 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033430 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Li B, Oestreich S, de Lange T (May 2000). "Identification of human Rap1: implications for telomere evolution". Cell. 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490. S2CID 7956545.
  6. ^ "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein".
  7. ^ a b c O'Connor MS, Safari A, Liu D, Qin J, Songyang Z (July 2004). "The human Rap1 protein complex and modulation of telomere length". The Journal of Biological Chemistry. 279 (27): 28585–91. doi:10.1074/jbc.M312913200. PMID 15100233.
  8. ^ Zhu XD, Küster B, Mann M, Petrini JH, de Lange T (July 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nature Genetics. 25 (3): 347–52. doi:10.1038/77139. PMID 10888888. S2CID 6689794.
  9. ^ Arat NÖ, Griffith JD (December 2012). "Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere". The Journal of Biological Chemistry. 287 (50): 41583–94. doi:10.1074/jbc.M112.415984. PMC 3516710. PMID 23086976.

Further reading edit