TAF4B

TAF4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H3O, 2P6V
Identifiers
Aliases	TAF4B, SPGF13, TAF2C2, TAFII105, TATA-box binding protein associated factor 4b
External IDs	OMIM: 601689 MGI: 2152345 HomoloGene: 28266 GeneCards: TAF4B
Gene location (Human)
Chr.	Chromosome 18 (human)
End	26,391,685 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	15,033,416 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Brodmann area 23; ; endothelial cell; ; middle temporal gyrus; ; Achilles tendon; ; tibialis anterior muscle; ; lymph node; ; thymus; ; tibia; ; lactiferous duct;
	Top expressed in
	hand; ; otolith organ; ; utricle; ; Paneth cell; ; cumulus cell; ; oocyte; ; secondary oocyte; ; ovary; ; facial motor nucleus; ; foot;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; NF-kappaB binding; protein heterodimerization activity; transcription coactivator activity; transcription factor binding; RNA polymerase II general transcription initiation factor activity;
Cellular component	cytoplasm; nucleus; nucleoplasm; fibrillar center; transcription factor TFIID complex;
Biological process	DNA-templated transcription, initiation; cell differentiation; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; transcription by RNA polymerase II; spermatogenesis; transcription, DNA-templated; oogenesis; regulation of signal transduction by p53 class mediator; positive regulation of transcription by RNA polymerase II; RNA polymerase II preinitiation complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	6875
	72504
	ENSG00000141384
	ENSMUSG00000054321
	Q92750
	G5E8Z2
	NM_001293725; NM_005640
	NM_001100449; NM_001369357; NM_001369358
	NP_001280654; NP_005631
	NP_001093919; NP_001356286; NP_001356287
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.^[5]^[6]^[7]

Function edit

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM]^[7]

Interactions edit

TAF4B has been shown to interact with RELA.^[8]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141384 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054321 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130". Cell. 87 (1): 137–46. doi:10.1016/S0092-8674(00)81330-6. PMID 8858156. S2CID 10194253.
^ Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes". J. Biol. Chem. 275 (24): 18180–7. doi:10.1074/jbc.275.24.18180. PMID 10849440.
^ ^a ^b "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa".
^ Yamit-Hezi A, Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.

Further reading edit

Liu WL, Coleman RA, Grob P, King DS, Florens L, Washburn MP, Geles KG, Yang JL, Ramey V, Nogales E, Tjian R (2008). "Structural changes in TAF4b-TFIID correlate with promoter selectivity". Mol. Cell. 29 (1): 81–91. doi:10.1016/j.molcel.2007.11.003. PMC 2486835. PMID 18206971.
Wu Y, Lu Y, Hu Y, Li R (2005). "Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line". J. Cell. Biochem. 96 (4): 751–9. doi:10.1002/jcb.20577. PMID 16088961. S2CID 23658728.
Shao H, Revach M, Moshonov S, Tzuman Y, Gazit K, Albeck S, Unger T, Dikstein R (2005). "Core promoter binding by histone-like TAF complexes". Mol. Cell. Biol. 25 (1): 206–19. doi:10.1128/MCB.25.1.206-219.2005. PMC 538770. PMID 15601843.
Rashevsky-Finkel A, Silkov A, Dikstein R (2001). "A composite nuclear export signal in the TBP-associated factor TAFII105". J. Biol. Chem. 276 (48): 44963–9. doi:10.1074/jbc.M106112200. PMID 11567023.
Wolstein O, Silkov A, Revach M, Dikstein R (2000). "Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription". J. Biol. Chem. 275 (22): 16459–65. doi:10.1074/jbc.275.22.16459. PMID 10828057.
Yamit-Hezi A, Dikstein R (1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141384 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054321 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8858156-5] Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130". Cell. 87 (1): 137–46. doi:10.1016/S0092-8674(00)81330-6. PMID 8858156. S2CID 10194253.

[pmid10849440-6] Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes". J. Biol. Chem. 275 (24): 18180–7. doi:10.1074/jbc.275.24.18180. PMID 10849440.

[entrez-7] "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa".

[pmid9724652-8] Yamit-Hezi A, Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.

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