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During her school days, Vani participated in various cultural programs. When she was in the 8th grade, she anchored children's programs on local cable TV in Vijayawada. After Intermediate, she took up anchoring as a profession.
Vani hosted shows such as Maa Talkies and Heart Beat with her husband on MAA TV. She appeared in Moguds Pellams, also directed by her husband.
She married Suresh Teja and has a daughter. Suresh Teja was a well-known TV director, who made several popular soaps and shows. He has also worked as a writer for TV serials. On 6 May 2019 Suresh Teja died in a hospital in Hyderabad due to prolonged illness. Surekha Vani had reduced her workload last year but never spoke about her husband's illness. The pair met years ago when she was just starting her career as an anchor. Teja gave her an opportunity to host a few TV shows like Moguds Pellams and Heartbeat. They started off as friends and eventually, they got hitched and had a baby girl.
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- "Surekha Vani interview - Telugu Cinema interview - Telugu film actress". Idlebrain.com. 21 August 2008. Retrieved 9 May 2013.