SC 185 begins at an intersection with US 178 (Old Shoals Junction Road) just southeast of Hodges, within Greenwood County. It travels to the northwest and nearly immediately enters the city limits of Hodges. It and US 178 take different paths through the town, and, at one point, are only about 100 feet (30 m) apart. SC 185 curves to the southwest and passes Hodges Elementary School before leaving town. The highway winds its way through rural areas of the county and enters Abbeville County just before crossing over Long Cane Creek. Approximately 2,000 feet (610 m) later, it intersects the northern terminus of SC 203 (Old Douglas Mill Road). It then travels to the northwest, going through Arborville, before it begins a concurrency with SC 20 (Greenville Street). They cross over Park Creek just before entering Due West. At North Main Street, they meet SC 184, which joins the concurrency. The three highways travel through Erskine College and pass Erskine Theological Seminary. Immediately afterward, SC 20/SC 185 splits off onto Anderson Drive. Just after leaving town, the concurrency crosses over Chickasaw Creek. They cross over Little Hogskin Creek and Hogskin Creek before splitting, with SC 185 going to the northwest. The highway crosses over Little River and then enters Anderson County. After a crossing of Camp Creek, is an intersection with SC 284 (Trail Road) in Saylors Crossroads. The highway crosses over Bear and Hencoop creeks before intersecting SC 413 in Ebenezer Crossroads. The highway curves to the northwest and crosses over Rocky River and meets its northern terminus, an intersection with SC 28 (Abbeville Highway).