Soluble quinoprotein glucose dehydrogenase (EC 1.1.99.35, soluble glucose dehydrogenase, sGDH, glucose dehydrogenase (PQQ-dependent)) is an enzyme with systematic name D-glucose:acceptor oxidoreductase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
| Soluble quinoprotein glucose dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.99.35 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- D-glucose + acceptor D-glucono-1,5-lactone + reduced acceptor
This soluble periplasmic enzyme contains PQQ as prosthetic group, and is bound to a calcium ion. Electron acceptor is not known.
References edit
- ^ Geiger O, Gorisch H (1986). "Crystalline quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus". Biochemistry. 25: 6043–6048. doi:10.1021/bi00368a031.
- ^ Dokter P, Frank J, Duine JA (October 1986). "Purification and characterization of quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus L.M.D. 79.41". The Biochemical Journal. 239 (1): 163–7. PMC 1147254. PMID 3800975.
- ^ Cleton-Jansen AM, Goosen N, Wenzel TJ, van de Putte P (May 1988). "Cloning of the gene encoding quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus: evidence for the presence of a second enzyme". Journal of Bacteriology. 170 (5): 2121–5. PMC 211095. PMID 2834325.
- ^ Matsushita K, Shinagawa E, Adachi O, Ameyama M (July 1989). "Quinoprotein D-glucose dehydrogenase of the Acinetobacter calcoaceticus respiratory chain: membrane-bound and soluble forms are different molecular species". Biochemistry. 28 (15): 6276–80. doi:10.1021/bi00441a020. PMID 2551369.
- ^ Oubrie A, Dijkstra BW (July 2000). "Structural requirements of pyrroloquinoline quinone dependent enzymatic reactions". Protein Science. 9 (7): 1265–73. doi:10.1110/ps.9.7.1265. PMC 2144678. PMID 10933491.
- ^ Matsushita, K.; Toyama, H.; Ameyama, M.; Adachi, O.; Dewanti, A.; Duine, J.A. (1995). "Soluble and membrane-bound quinoprotein D-glucose dehydrogenases of the Acinetobacter calcoaceticus : the binding process of PQQ to the apoenzymes". Biosci. Biotechnol. Biochem. 59: 1548–1555. doi:10.1271/bbb.59.1548.
External links edit
- Soluble+quinoprotein+glucose+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
