Sodium trichloroacetate is a chemical compound with a formula of CCl3CO2Na. It is used to increase sensitivity and precision during transcript mapping.
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||185.36 g/mol|
|Melting point||200 °C (392 °F; 473 K)|
|55 g / 100 ml|
|Solubility||Soluble in methanol and ethanol, slightly soluble in acetone, not soluble in ethers and hydrocarbons|
|Acidity (pKa)||0.7 (conjugate acid)|
|GHS Signal word||Warning|
|H335, H400, H410|
|P261, P271, P273, P304+340, P312, P391, P403+233, P405, P501|
|NFPA 704 (fire diamond)|
|Sodium chloroacetate |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Sodium trichloroacetate is made by reaction trichloroacetic acid with sodium hydroxide:
Compared to sodium acetate, The basicity of sodium trichloroacetate is weaker because of the electron-withdrawing nature of the trichloromethyl group. Sodium trifluoroacetate is an even weaker base than that due to higher electronegativity of fluorine atoms. In the presence of strong acids the anion can be protonated: