Simeon served as the Bishop of Polotsk before being elected as the metropolitan bishop by the council of bishops. He was later confirmed by the Patriarch of Constantinople in 1481. Evidence of confirmation of Simeon according to Hrushevsky is mentioned in a palinode of Zachary Kopystensky. With this confirmation also was restored so called "modus vivendi".
The tenure of Simeon was challenged by the anti-Eastern Orthodox sentiments of the King of Poland Casimir IV Jagiellon and the 1482 plundering of Kiev by the Crimean Khan Mengli Giray, an ally of the Grand Prince Ivan III of Moscow.