|Previous owners||Block Drug|
Sensodyne toothpastes work in different ways depending on the product's active ingredient - potassium nitrate, strontium acetate/chloride.
Strontium acetate and strontium chloride: These compounds share a similar chemical structure to calcium. Strontium based toothpastes (acetate and chloride) are therefore able to replace some of the lost calcium and block the exposed tubules in the dentinal tissue. This helps prevent the movement of the fluid within the tubules in response to a sensitivity stimulus that could otherwise cause tooth pain.
Some Sensodyne products contain calcium sodium phosphosilicate CSPS (Novamin), which appears to help with tooth sensitivity. A randomized clinical trial published in 2015 demonstrated that dentifrices containing 5% CSPS may have the potential to mineralize and occlude the dentine in the oral environment. Sensodyne products sold in the United States do not contain calcium sodium phosphosilicate (Novamin).
The toothpaste was first marketed in 1961 as a desensitising toothpaste based on a strontium chloride formulation. In 1980, Sensodyne launched a new toothpaste containing potassium nitrate, a mild local sedative.
Product counterfeits and recallEdit
In 2007, GlaxoSmithKline tracked down counterfeit producers of Sensodyne after a consumer in Panama noted diethylene glycol, a poisonous ingredient commonly found in antifreeze, on the label of his toothpaste.
On July 15, 2015, GlaxoSmithKline Consumer Healthcare announced a recall of certain lots of Sensodyne Repair & Protect toothpaste as well as Sensodyne Complete toothpaste due to the possible presence of wood fragments in the products. The recall also applied to the company's Biotene brand of toothpaste. The recall was a precautionary measure based on a small number of complaints, and no injuries have been reported. The recall applies to products manufactured between 2013 and September 2014, and shipped from June 2013 to April 2015.
- Clark, Andrew (October 7, 2000). "SmithKline to swallow Sensodyne". The Guardian. Retrieved July 20, 2013.
- "Archived copy". Archived from the original on 2013-03-05. Retrieved 2013-03-17.CS1 maint: archived copy as title (link)
- Walsh, Margaret (Apr 15, 2014). Dental Hygiene: Theory and Practice. Elsevier Health Sciences. p. 699. ISBN 9781455745845.
- Hughes, N; Layer, T (2010). "Evidence for the efficacy of an 8% strontium acetate dentifrice for instant and lasting relief of dentin hypersensitivity". Journal of Clinical Dentistry. 21 (5): 56–58. PMID 20669817.
- Freda, Nicolas M; Veitz-Keenan, Analia (March 2016). "Calcium sodium phosphosilicate had some benefit on dentine hypersensitivity: Question: Is calcium sodium phosphosilicate (CSPS) effective in reducing dentine hypersensitivity (DH) pain response?". Evidence-Based Dentistry. 17 (1): 12–13. doi:10.1038/sj.ebd.6401148. ISSN 1462-0049. PMID 27012568. S2CID 24049298.
- Goldie, Maria. "Potassium nitrate, sodium fluoride, strontium chloride, and NovaMin technologies for dentin hypersensitivity". Dentistry IQ. Retrieved 21 November 2014.
- Jones, Siân Bodfel; Parkinson, Charles R.; Jeffery, Peter; Davies, Maria; Macdonald, Emma L.; Seong, Joon; West, Nicola X. (June 2015). "A randomised clinical trial investigating calcium sodium phosphosilicate as a dentine mineralising agent in the oral environment". Journal of Dentistry. 43 (6): 757–764. doi:10.1016/j.jdent.2014.10.005. PMID 25456613.
- Hall, Claire; Mason, Stephen; Cooke, Jonathan (May 2017). "Exploratory randomised controlled clinical study to evaluate the comparative efficacy of two occluding toothpastes – a 5% calcium sodium phosphosilicate toothpaste and an 8% arginine/calcium carbonate toothpaste – for the longer-term relief of dentine hypersensitivity". Journal of Dentistry. 60: 36–43. doi:10.1016/j.jdent.2017.02.009. PMID 28219674.
- United States National Institutes of Health, National Library of Medicine, SENSODYNE REPAIR AND PROTECT - stannous fluoride paste.
- Saxon, Wolfgang (2005-11-12). "Leonard Block, 93, Chief of Drug Company, Is Dead". The New York Times. ISSN 0362-4331. Retrieved 2019-09-30.
- News, Bloomberg (2000-10-10). "Company News; Smithkline to Buy Block Drug for $1.2 Billion". The New York Times. ISSN 0362-4331. Retrieved 2019-09-30.
- "Firms Complete Merger of GlaxoSmithKline". Los Angeles Times. 2000-12-28. Retrieved 2019-09-30.
- Ramirez, Anthony (May 13, 1990). "All About/Toothpaste; Growth Is Glacial, but the Market Is Big, and So Is the Gross". The New York Times. Retrieved July 20, 2013.
- Colgate and Sensodyne, got caught up in the sweep when counterfeiters were found to be selling toothpaste with antifreeze under their names. BOGDANICH, WALT (October 1, 2007). "The Everyman Who Exposed Tainted Toothpaste". The New York Times. Retrieved 2 April 2019.
- "Urgent: Product Recall - Retail Level" (PDF). Smith Drug. 15 July 2015.