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Sclerosis is the stiffening of a structure, usually caused by a replacement of the normal organ-specific tissue with connective tissue. The structure may be said to have undergone sclerotic changes or display sclerotic lesions, which refers to the process of sclerosis. The term is from Greek σκληρός "hard".

Other namesSclerosus
Lichen sclerosus - very high mag.jpg
Micrograph of subepithelial sclerosus (middle third of image) in a case of lichen sclerosus. H&E stain.

Common medical conditions whose pathology involves sclerosis include:


  1. ^ "Welcome To The NephCure Foundation". Archived from the original on 2009-06-02.
  2. ^ "Focal sclerosis definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms". 2012-09-20. Retrieved 2013-01-12.

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