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Humphrey was born with a rare genetic disorder called acrodysplasia. As a child he was also diagnosed with the inflammatory bowel condition Crohn's disease and has spent a lifetime visiting hospitals and doctors' offices for operations and tests, and was not expected to reach his teenage years, let alone adulthood.
In an interview, he said that he had attempted suicide several times, but with support from his family, his faith and his resilience, he was able to overcome his challenges and pursue his dream of becoming an actor. His surgery was scheduled in September 2018.
Humphrey has two siblings, his older brother is entrepreneur Josiah Humphrey, whom co-founded the Tech company Appster in 2011.
Humphrey attended Tawa intermediate, Wellington, New Zealand in 2006.
Humphrey is of half Asian descent.
Prior to his professional debut, Humphrey appeared in numerous school productions.
Humphrey began his acting career in television, his first role on Neighbours, where he appeared on four episodes. He made his film debut in the historical period drama musical film The Greatest Showman, he played Charles Stratton, a dwarf performer who is also known by his stage name of General Tom Thumb. As he is taller than the real Tom Thumb, he had to walk on his knees and his voice was digitally altered to sound deeper.
In 2017, Humphrey starred in the television film Jeremy the Dud.
|2017||The Greatest Showman||Charles Stratton|
|2016–17||Neighbours||James Udagawa||4 episodes|
|2017||Jeremy the Dud||Jai||Television film|
- "Sam Humphrey on the Biggest Lesson Hugh Jackman Taught Him on 'Greatest Showman'". Entertainment Tonight. 30 January 2018. Retrieved 3 February 2018.
- "Sam Humphrey overcomes rare disease to star in The Greatest Showman". News.com.au.
- "The Greatest Showman's Sam Humphrey Is Undergoing High-Risk Surgery". Us Weekly. 2018-09-06. Retrieved 2018-09-07.
- "The Greatest Showman's Sam Humphrey Undergoing 'High-Risk' Surgery Due to Crohn's Disease". PEOPLE.com. Retrieved 2018-09-07.
- Molina, Jess (20 March 2018). "Sam Humphrey is The Greatest Showman".
- Thompson, Melissa (23 January 2018). "The Greatest Snowman's Sam Humphrey: A Star in the Making". We Are Movie Geeks. Retrieved 3 February 2018.
- Findlay, Carly (November 5, 2017). "Jeremy the Dud: the new short film that flips disability on its head". The Guardian.