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Signal recognition particle receptor subunit beta is a protein that in humans is encoded by the SRPRB gene.[5][6][7]

Protein SRPRB PDB 2fh5.png
AliasesSRPRB, APMCF1, SRP receptor beta subunit, SRP receptor subunit beta
External IDsMGI: 102964 HomoloGene: 6332 GeneCards: SRPRB
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SRPRB
Genomic location for SRPRB
Band3q22.1Start133,784,033 bp[1]
End133,825,772 bp[1]
RNA expression pattern
PBB GE SRPRB gnf1h07233 at fs.png

PBB GE SRPRB 218140 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 133.78 – 133.83 MbChr 9: 103.19 – 103.2 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144867 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032553 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Miller JD, Tajima S, Lauffer L, Walter P (Mar 1995). "The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane". J Cell Biol. 128 (3): 273–82. doi:10.1083/jcb.128.3.273. PMC 2120348. PMID 7844142.
  6. ^ Legate KR, Falcone D, Andrews DW (Oct 2000). "Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit". J Biol Chem. 275 (35): 27439–46. doi:10.1074/jbc.M003215200. PMID 10859309.
  7. ^ a b "Entrez Gene: SRPRB signal recognition particle receptor, B subunit".

Further readingEdit