SPTBN5

SPTBN5
Identifiers
Aliases	SPTBN5, BSPECV, HUBSPECV, HUSPECV, spectrin beta, non-erythrocytic 5
External IDs	OMIM: 605916 MGI: 2685200 HomoloGene: 41150 GeneCards: SPTBN5
Gene location (Human)
Chr.	Chromosome 15 (human)
End	41,894,053 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	119,916,159 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; cerebellar hemisphere; ; retinal pigment epithelium; ; skin of abdomen; ; left ventricle; ; right lobe of thyroid gland; ; right lobe of liver; ; trigeminal ganglion; ; left lobe of thyroid gland; ; minor salivary glands;
	Top expressed in
	esophagus; ; hypothalamus; ; muscle tissue; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; lip; ; zone of skin; ; islet of Langerhans; ; ovary; ; white adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	dynactin binding; protein self-association; kinesin binding; myosin tail binding; actin binding; dynein intermediate chain binding; spectrin binding;
Cellular component	cytoplasm; cytosol; spectrin; membrane; photoreceptor connecting cilium; photoreceptor disc membrane; cytoskeleton; microtubule organizing center; filamentous actin;
Biological process	Golgi organization; MAPK cascade; axon guidance; endoplasmic reticulum to Golgi vesicle-mediated transport; actin filament capping; lysosomal transport; protein homooligomerization; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	51332
	640524
	ENSG00000137877
	ENSMUSG00000074899
	Q9NRC6
	n/a
	NM_016642
	NM_001370938
	NP_057726
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Spectrin, beta, non-erythrocytic 5 also known as SPTBN5 is a protein that in humans is encoded by the SPTBN5 gene.^[5] SPTBN5 belongs to the spectrin family of cytoskeletal proteins.

Structure and function edit

SPTBN5 contains the following domains:^[5]

actin-binding domain
membrane-association domain-1
self-association domain
C-terminal pleckstrin homology domain.

Based on these structural features it is thought that SPTBN5 is likely to form heterodimers and oligomers with alpha-spectrin and to interact directly with cellular membranes.^[5]

SPTBN5 is highly expressed in embryoid bodies.^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137877 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074899 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Stabach PR, Morrow JS (July 2000). "Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin". J. Biol. Chem. 275 (28): 21385–95. doi:10.1074/jbc.C000159200. PMID 10764729.
^ Chaerkady R, Kerr CL, Marimuthu A, Kelkar DS, Kashyap MK, Gucek M, Gearhart JD, Pandey A (January 2009). "Temporal analysis of neural differentiation using quantitative proteomics". J. Proteome Res. 8 (3): 1315–26. doi:10.1021/pr8006667. PMC 2693473. PMID 19173612.

Further reading edit

Odell AF, Van Helden DF, Scott JL (2008). "The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels". J. Biol. Chem. 283 (7): 4395–407. doi:10.1074/jbc.M709729200. hdl:1959.13/39937. PMID 18048348.
Oguri M, Kato K, Yokoi K, et al. (2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
Shoeman RL, Hartig R, Hauses C, Traub P (2002). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease". Cell Biol. Int. 26 (6): 529–39. doi:10.1006/cbir.2002.0895. PMID 12119179. S2CID 39778155.
Chardin P, Camonis JH, Gale NW, et al. (1993). "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2". Science. 260 (5112): 1338–43. Bibcode:1993Sci...260.1338C. doi:10.1126/science.8493579. PMID 8493579.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137877 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074899 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10764729-5] Stabach PR, Morrow JS (July 2000). "Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin". J. Biol. Chem. 275 (28): 21385–95. doi:10.1074/jbc.C000159200. PMID 10764729.

[pmid19173612-6] Chaerkady R, Kerr CL, Marimuthu A, Kelkar DS, Kashyap MK, Gucek M, Gearhart JD, Pandey A (January 2009). "Temporal analysis of neural differentiation using quantitative proteomics". J. Proteome Res. 8 (3): 1315–26. doi:10.1021/pr8006667. PMC 2693473. PMID 19173612.

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