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Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene.[5][6]

SPA17
Identifiers
AliasesSPA17, CT22, SP17, SP17-1, sperm autoantigenic protein 17
External IDsOMIM: 608621 MGI: 1333778 HomoloGene: 7951 GeneCards: SPA17
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SPA17
Genomic location for SPA17
Band11q24.2Start124,673,798 bp[1]
End124,697,518 bp[1]
RNA expression pattern
PBB GE SPA17 205406 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017425

NM_011449
NM_001324545

RefSeq (protein)

NP_059121

NP_001311474
NP_035579

Location (UCSC)Chr 11: 124.67 – 124.7 MbChr 9: 37.6 – 37.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein present at the cell surface. Studies in rabbits suggest that in sperm the protein is involved in fertilization by binding to the zona pellucida of the oocyte. Other studies in rabbits suggest that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis.[6]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000064199 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001948 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Lea IA, Richardson RT, Widgren EE, O'Rand MG (Aug 1996). "Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17". Biochim Biophys Acta. 1307 (3): 263–6. doi:10.1016/0167-4781(96)00077-2. PMID 8688458.
  6. ^ a b "Entrez Gene: SPA17 sperm autoantigenic protein 17".

Further readingEdit