S.M., also sometimes referred to as SM-046, is a female patient first described in 1994 who has had exclusive and complete bilateral amygdala destruction since late childhood as a consequence of an extremely rare genetic condition known as Urbach–Wiethe disease. S.M. is notable in that, because of this damage, she has little to no capacity to experience fear in her life, a characteristic which has resulted in her being dubbed by the media as the "woman with no fear". S.M. has been studied extensively in scientific research, and has helped researchers to elucidate the function of the amygdala.
Experiments with S.M. revealed no fear in response to exposure to or handling of snakes and spiders (including tarantulas), a walk through a haunted attraction (Waverly Hills Sanatorium, specifically), or fear-inducing film clips (e.g., The Blair Witch Project, The Shining, and The Silence of the Lambs), instead only interest, curiosity, and excitement, though she also expressed emotions appropriate to the film content such as happiness and disgust when viewing non fear-inducing film clips. Research has revealed that S.M. is not immune to all fear, however; along with other patients with bilateral amygdala damage, she was found to experience fear and panic attacks of greater intensity than the neurologically healthy controls in response to simulation of the subjective experience of suffocation via carbon dioxide inhalation, feelings which she and the others described as completely novel to them.
S.M. is described as very outgoing, extremely friendly, and disinhibited, as well as "somewhat coquettish" (playfully flirtatious) and having an abnormally high desire and tendency to approach others. She is greatly impaired in recognizing negative social cues, such as being incapable of recognizing fear in the facial expressions of other people and having difficulty judging trustworthiness and approachability in the faces of others. These traits show consistency with the fact that she tends to quite indiscriminately approach and engage in physical contact with others. In addition, S.M. appears to experience relatively little negative emotion, whilst simultaneously experiencing a relatively high degree of positive affect, despite great adversity in her life. In accordance, she tends to be very positive about most people, situations, and issues. S.M. also exhibits impairments in the emotional processing of music; specifically, she shows selectively impaired recognition of sad and scary music.
In addition to her lack of fear, S.M. shows a lack of a sense of personal space, and experiences virtually no discomfort standing extremely close to strangers, even nose-to-nose with direct eye contact. She does understand the concept of personal space, however, and acknowledges that other people need more personal space than she does. S.M. also shows memory differences. Emotionally arousing stimuli are known to undergo an enhancement of consolidation into long-term declarative memory (see emotion and memory), and this effect appears to be dependent on the amygdala. In accordance, S.M. displays impaired declarative memory facilitation for emotional material, while her memory consolidation for neutral material is normal. SM still capable of being empathic to others despite being less capable of detecting negative emotion from faces, however her threshold for noticing another person's pain was described as “fairly high”. 
In her personal life, S.M. has been the victim of numerous acts of crime and traumatic and life-threatening encounters. She has been held up at both knifepoint and gunpoint, was almost killed in a domestic violence incident, and has received explicit death threats on multiple occasions. Despite the life-threatening nature of many of these situations, S.M. did not exhibit any signs of desperation, urgency, or other behavioral responses that would normally be associated with such incidents. The disproportionate number of traumatic events in S.M.'s life has been attributed to a combination of her living in a dangerous area filled with poverty, crime, and drugs, and to a marked impairment on her part of detecting looming threats in her environment and learning to steer clear of potentially dangerous situations. S.M. herself has never been convicted of a crime.
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