The gene rpoF (RNA polymerase, flagellum F) encodes the sigma factor sigma-28 (σ28, or RpoF), a protein in Escherichia coli and other species of bacteria. Depending on the bacterial species, this gene may be referred to as sigD[1] or fliA.[2] The protein encoded by this gene has been found to be necessary for flagellum formation.[3][4][5]


  1. ^ Helmann, JD; Márquez, LM; Chamberlin, MJ (Apr 1988). "Cloning, sequencing, and disruption of the Bacillus subtilis sigma 28 gene". Journal of Bacteriology. 170 (4): 1568–74. PMC 211003. PMID 2832368.
  2. ^ Fitzgerald, DM; Bonocora, RP; Wade, JT (Oct 2014). "Comprehensive Mapping of the Escherichia coli Flagellar Regulatory Network". PLOS Genetics. 10 (10): e1004649. doi:10.1371/journal.pgen.1004649. PMC 4183435. PMID 25275371.
  3. ^ Makinoshima, H.; Aizawa, S.-I.; Hayashi, H.; Miki, T.; Nishimura, A.; Ishihama, A. (15 February 2003). "Growth Phase-Coupled Alterations in Cell Structure and Function of Escherichia coli". Journal of Bacteriology. 185 (4): 1338–1345. doi:10.1128/JB.185.4.1338-1345.2003. PMC 142870. PMID 12562804.
  4. ^ Starnbach, M. N.; Lory, S. (1992). "The filA (rpoF) gene of Pseudomonas aeruginosa encodes an alternative sigma factor required for flagellin synthesis". Molecular Microbiology. 6 (4): 459–469. doi:10.1111/j.1365-2958.1992.tb01490.x.
  5. ^ Prouty, Michael G.; Correa, Nidia E.; Klose, Karl E. (2001). "The novel sigma54- and sigma28-dependent flagellar gene transcription hierarchy of Vibrio cholerae". Molecular Microbiology. 39 (6): 1595–1609. doi:10.1046/j.1365-2958.2001.02348.x.