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The hindbrain or rhombencephalon is a developmental categorization of portions of the central nervous system in vertebrates. It includes the medulla, pons, and cerebellum. Together they support vital bodily processes.
Scheme of roof of fourth ventricle.
|Anatomical terms of neuroanatomy|
The hindbrain can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh8-Rh1. Rostrally, the isthmus demarcates the boundary with the midbrain.
The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure.
Rhombomeres Rh3-Rh1 form the metencephalon.
Rhombomeres Rh8-Rh4 form the myelencephalon.
The myelencephalon forms the medulla oblongata in the adult brain; it contains:
The hindbrain is homologous to a part of the arthropod brain known as the sub-oesophageal ganglion, in terms of the genes that it expresses and its position in between the brain and the nerve cord. On this basis, it has been suggested that the hindbrain first evolved in the Urbilaterian—the last common ancestor of chordates and arthropods—between 570 and 555 million years ago.
A rare brain malformation of the cerebellum is rhombencephalosynapsis characterized by an absent or partially formed vermis. Symptoms can include ataxia. The disorder is a main feature of Gomez-Lopez-Hernandez syndrome.
Chicken embryo of thirty-three hours’ incubation, viewed from the dorsal aspect. X 30.
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