|Other names||Aplastic crisis, Marrow failure|
Reticulocytopenia is usually a result of viral parvovirus B19 infection, which invades and destroys red blood cell precursors and halts the red cell production.
If infection occurs in individuals with sickle cell anemia, spherocytosis, or beta thalassemia, it will lead to incorporation of two anemia-induced mechanisms: decreased red cell production and hemolysis. The result is a rapid and severe anemia (aplastic crisis) which may require blood transfusion.
- "Sickle Cell Disease - Basic Principles and Clinical Practice" Edited by Stephen H. Embury, Robert P. Hebbel, Narla Mohandas and Martin Steinberg. Copyright 1996 by Lippincott-Raven. Section IV p352.