Reginald II was the count of Burgundy, Mâcon, Vienne and Oltingen. He was born in 1061 as the eldest son of William I of Burgundy and brother to Stephen I of Burgundy, his successor, as well as to Pope Callixtus II.
He succeeded to the county, aged 25, on his father's death in 1087, also gaining th County of Mâcon.
By his marriage to Regina of Oltingen, he obtained the County of Oltingen. They were the parents of William II of Burgundy.
The place and date of his death is uncertain, as is his potential participation in the First Crusade. His death is dated either to 1095, prior to the First Crusade  or to circa 1102 in the Holy Land  along with his brothers Stephen I and Hugh, archbishop of Besançon.
- Sword, Miter and Cloister: Nobility and the Church in Burgundy, 980-1198, Constance Brittain Bouchard (Cornell University Press; Ithaca, NY; 1982)
- The Crusade of 1101, James Lea Cate, A History of the Crusades: The First Hundred Years, ed.Kenneth Meyer Setton and M. W. Baldwin, (The University of Wisconsin Press, 1969), 363.
- The Crusade of 1101, James Lea Cate, A History of the Crusades: The First Hundred Years, 350.