Reginald II may refer to:
- Reginald II, Count of Burgundy (1061–1097), Count Palatine of Burgundy and Count of Mâcon from 1087
- Reginald II, Count of Bar (died 1170), Count of Bar and Lord of Mousson from 1149
- Reginald II, Duke of Guelders (c. 1295–1343), called "the Black", Count of Guelders from 1318, Duke of Guelders from 1339, and Count of Zutphen from 1326 to 1343
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