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60S ribosomal protein L12

  (Redirected from RPL12)

60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.[5][6]

RPL12
Protein RPL12 PDB 1wib.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPL12, L12, ribosomal protein L12
External IDsOMIM: 180475 MGI: 98002 HomoloGene: 128047 GeneCards: RPL12
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for RPL12
Genomic location for RPL12
Band9q33.3Start127,447,674 bp[1]
End127,451,406 bp[1]
RNA expression pattern
PBB GE RPL12 200809 x at fs.png

PBB GE RPL12 214271 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000976

NM_009076

RefSeq (protein)

NP_000967

NP_033102

Location (UCSC)Chr 9: 127.45 – 127.45 MbChr 2: 32.96 – 32.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FunctionEdit

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

InteractionsEdit

RPL12 has been shown to interact with CDC5L.[7]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197958 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038900 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chu W, Presky DH, Swerlick RA, Burns DK (March 1993). "The primary structure of human ribosomal protein L12". Nucleic Acids Res. 21 (3): 749. doi:10.1093/nar/21.3.749. PMC 309184. PMID 8441690.
  6. ^ a b "Entrez Gene: RPL12 ribosomal protein L12".
  7. ^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further readingEdit

External linksEdit

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L12