RNR3

RNA, ribosomal 3, also known as RNR3, is a human gene. It is a minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes the rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog, RNR1, that arose from the whole genome duplication.

RNR3
Identifiers
Aliases	RNR3, RNA, ribosomal 45S cluster 3
External IDs	OMIM: 180452 GeneCards: RNR3
Orthologs Species Human Mouse Entrez 6054 n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Nucleolus organizer regions are chromosomal regions crucial for the formation of the nucleolus, located on the short arms of the acrocentric chromosomes 13, 14, 15, 21 and 22
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• McCallum FS, Maden BE (1986). "Human 18 S ribosomal RNA sequence inferred from DNA sequence. Variations in 18 S sequences and secondary modification patterns between vertebrates". Biochem. J. 232 (3): 725–733. doi:10.1042/bj2320725. PMC 1152944. PMID 4091818.
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• Gonzalez IL, Sylvester JE (1995). "Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer". Genomics. 27 (2): 320–328. doi:10.1006/geno.1995.1049. PMID 7557999.
• Gonzalez IL, Sylvester JE (2001). "Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes". Genomics. 73 (3): 255–263. doi:10.1006/geno.2001.6540. PMID 11350117.