RMBase (RNA Modification Base)

RMBase (RNA Modification Base) [1][2] is designed for decoding the landscape of RNA modifications identified from high-throughput sequencing data (MeRIP-seq, m6A-seq, miCLIP, m6A-CLIP, Pseudo-seq, Ψ-seq, CeU-seq, Aza-IP, RiboMeth-seq). It contains ~124200 N6-Methyladenosines (m6A), ~9500 pseudouridine (Ψ) modifications, ~1000 5-methylcytosine (m5C) modifications, ~1210 2′-O-methylations (2′-O-Me) and ~3130 other types of RNA modifications. RMBase demonstrated thousands of RNA modifications located within mRNAs, regulatory ncRNAs (e.g. lncRNAs, miRNAs, pseudogenes, circRNAs, snoRNAs, tRNAs), miRNA target sites and disease-related SNPs.

RMBase
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Content
Descriptiondecoding the landscape of RNA modifications identified from high-throughput sequencing datasets.
Contact
Research centerSun Yat-sen University
LaboratoryKey Laboratory of Gene Engineering of the Ministry of Education
AuthorsJian-Hua Yang
Primary citationSun & al. (2015)[1]
Release date2010
Access
Websitehttp://rna.sysu.edu.cn/rmbase/

See alsoEdit

ReferencesEdit

  1. ^ a b Sun, WJ; Li, JH; Liu, S; Wu, J; Zhou, H; Qu, LH; Yang, JH (11 October 2015). "RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data". Nucleic Acids Research. 44: gkv1036. doi:10.1093/nar/gkv1036. PMC 4702777. PMID 26464443.
  2. ^ Xuan, JJ; Sun, WJ; Lin, PH; Zhou, KR; Liu, S; Zheng, LL; Qu, LH; Yang, JH (4 January 2018). "RMBase v2.0: deciphering the map of RNA modifications from epitranscriptome sequencing data". Nucleic Acids Research. 46 (D1): D327–D334. doi:10.1093/nar/gkx934. PMC 5753293. PMID 29040692.

External linksEdit