RAPGEF5

RAPGEF5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGY
Identifiers
Aliases	RAPGEF5, GFR, MR-GEF, REPAC, Rap guanine nucleotide exchange factor 5, MRGEF
External IDs	OMIM: 609527 MGI: 2444365 HomoloGene: 56563 GeneCards: RAPGEF5
Gene location (Human)
Chr.	Chromosome 7 (human)
End	22,357,154 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	117,723,472 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; pons; ; inferior olivary nucleus; ; corpus callosum; ; superior vestibular nucleus; ; subthalamic nucleus; ; postcentral gyrus; ; external globus pallidus; ; Brodmann area 23; ; ventral tegmental area;
	Top expressed in
	superior cervical ganglion; ; otolith organ; ; utricle; ; right lung; ; left lung lobe; ; oocyte; ; secondary oocyte; ; right lung lobe; ; cingulate gyrus; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP-dependent protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	nucleus; nucleoplasm; nuclear body;
Biological process	small GTPase mediated signal transduction; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	9771
	217944
	ENSG00000136237
	ENSMUSG00000041992
	Q92565
	Q8C0Q9
	NM_012294; NM_001367600; NM_001367601; NM_001367602; NM_001367603
	NM_175930; NM_001373989
	NP_036426; NP_001354529; NP_001354530; NP_001354531; NP_001354532
	NP_787126; NP_001360918
	Wikidata
View/Edit Human	View/Edit Mouse

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.^[5]^[6]^[7]

Members of the RAS subfamily (see HRAS; MIM 190020) of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM]^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136237 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041992 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
^ Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y (Oct 1999). "Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1". FEBS Lett. 457 (1): 85–9. doi:10.1016/S0014-5793(99)01012-1. PMID 10486569. S2CID 20296877.
^ ^a ^b "Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5".

Further reading edit

de Rooij J, Rehmann H, van Triest M, et al. (2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs". J. Biol. Chem. 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494.
Rebhun JF, Castro AF, Quilliam LA (2001). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J. Biol. Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dupuy AG, L'Hoste S, Cherfils J, et al. (2005). "Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac". Oncogene. 24 (28): 4509–20. doi:10.1038/sj.onc.1208647. PMID 15856025.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136237 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041992 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9039502-5] Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.

[pmid10486569-6] Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y (Oct 1999). "Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1". FEBS Lett. 457 (1): 85–9. doi:10.1016/S0014-5793(99)01012-1. PMID 10486569. S2CID 20296877.

[entrez-7] "Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5".

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