RAI2

Retinoic acid-induced protein 2 is a protein that in humans is encoded by the RAI2 gene.

RAI2
Identifiers
Aliases	RAI2, retinoic acid induced 2
External IDs	OMIM: 300217 MGI: 1344378 HomoloGene: 11034 GeneCards: RAI2
Gene location (Human) Chr. X chromosome (human) Band Xp22.13 Start 17,800,049 bp End 17,861,337 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X F4 Start 160,500,065 bp End 160,562,492 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube urethra right lung canal of the cervix saphenous vein gastric mucosa vena cava myometrium lower lobe of lung subcutaneous adipose tissue Top expressed in myocardium of ventricle intercostal muscle cumulus cell supraoptic nucleus pineal gland aortic valve islet of Langerhans ganglionic eminence medial ganglionic eminence soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component cellular component Biological process embryo development ending in birth or egg hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10742 24004 Ensembl ENSG00000131831 ENSMUSG00000043518 UniProt Q9Y5P3 Q9QVY8 RefSeq (mRNA) NM_001172732 NM_001172739 NM_001172743 NM_021785 NM_001103367 NM_198409 RefSeq (protein) NP_001166203 NP_001166210 NP_001166214 NP_068557 NP_001166210.1 NP_001166214.1 NP_068557.3 NP_001096837 NP_940801 Location (UCSC) Chr X: 17.8 – 17.86 Mb Chr X: 160.5 – 160.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This article is about the protein. For the Italian television channel, see Rai 2.

Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this intronless, retinoic acid-induced gene has not yet been determined; however, it has been suggested to play a role in development. Localization of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome.

Further reading

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.