Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.[5]

RAB7B
Identifiers
AliasesRAB7B, RAB7, member RAS oncogene family
External IDsMGI: 2442295 HomoloGene: 64833 GeneCards: RAB7B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164522
NM_001304839
NM_177403

NM_145509
NM_001311096

RefSeq (protein)

NP_001157994
NP_001291768
NP_796377

NP_001298025
NP_663484

Location (UCSC)Chr 1: 205.98 – 206 MbChr 1: 131.62 – 131.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells.[6] By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.[6]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000276600 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052688 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yang M, Chen T, Han C, Li N, Wan T, Cao X (June 2004). "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells". Biochem. Biophys. Res. Commun. 318 (3): 792–9. doi:10.1016/j.bbrc.2004.04.115. PMID 15144907.
  6. ^ a b Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X (August 2007). "Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4". Blood. 110 (3): 962–71. doi:10.1182/blood-2007-01-066027. PMID 17395780. S2CID 28664736.

Further reading edit