Quantum biology

Quantum biology is the study of applications of quantum mechanics and theoretical chemistry to biological objects and problems. Many biological processes involve the conversion of energy into forms that are usable for chemical transformations, and are quantum mechanical in nature. Such processes involve chemical reactions, light absorption, formation of excited electronic states, transfer of excitation energy, and the transfer of electrons and protons (hydrogen ions) in chemical processes, such as photosynthesis, olfaction and cellular respiration.[1]

Quantum biology may use computations to model biological interactions in light of quantum mechanical effects.[2] Quantum biology is concerned with the influence of non-trivial quantum phenomena,[3] which can be explained by reducing the biological process to fundamental physics, although these effects are difficult to study and can be speculative.[4]


Quantum biology is an emerging field; most of the current research is theoretical and subject to questions that require further experimentation. Though the field has only recently received an influx of attention, it has been conceptualized by physicists throughout the 20th century. It has been suggested that quantum biology might play a critical role in the future of the medical world.[5] Early pioneers of quantum physics saw applications of quantum mechanics in biological problems. Erwin Schrödinger's 1944 book What is Life? discussed applications of quantum mechanics in biology.[6] Schrödinger introduced the idea of an "aperiodic crystal" that contained genetic information in its configuration of covalent chemical bonds. He further suggested that mutations are introduced by "quantum leaps". Other pioneers Niels Bohr, Pascual Jordan, and Max Delbruck argued that the quantum idea of complementarity was fundamental to the life sciences.[7] In 1963, Per-Olov Löwdin published proton tunneling as another mechanism for DNA mutation. In his paper, he stated that there is a new field of study called "quantum biology".[8]



Diagram of FMO complex. Light excites electrons in an antenna. The excitation then transfers through various proteins in the FMO complex to the reaction center to further photosynthesis.

Organisms that undergo photosynthesis absorb light energy through the process of electron excitation in antennae. These antennae vary among organisms. For example, bacteria use ring-like antennae, while plants use chlorophyll pigments to absorb photons. Photosynthesis creates Frenkel excitons, which provide a separation of charge that cells convert into usable chemical energy. The energy collected in reaction sites must be transferred quickly before it is lost to fluorescence or thermal vibrational motion.

Various structures, such as the FMO complex in green sulfur bacteria, are responsible for transferring energy from antennae to a reaction site. FT electron spectroscopy studies of electron absorption and transfer show an efficiency of above 99%,[9] which cannot be explained by classical mechanical models like the diffusion model. Instead, as early as 1938, scientists theorized that quantum coherence was the mechanism for excitation energy transfer.

Scientists have recently looked for experimental evidence of this proposed energy transfer mechanism. A study published in 2007 claimed the identification of electronic quantum coherence[10] at −196 °C (77 K). Another theoretical study from 2010 provided evidence that quantum coherence lives as long as 300 femtoseconds at biologically relevant temperatures (4 °C or 277 K) . In that same year, experiments conducted on photosynthetic cryptophyte algae using two-dimensional photon echo spectroscopy yielded further confirmation for long-term quantum coherence.[11] These studies suggest that, through evolution, nature has developed a way of protecting quantum coherence to enhance the efficiency of photosynthesis. However, critical follow-up studies question the interpretation of these results. Single molecule spectroscopy now shows the quantum characteristics of photosynthesis without the interference of static disorder, and some studies use this method to assign reported signatures of electronic quantum coherence to nuclear dynamics occurring in chromophores.[12][13][14][15][16][17][18] A number of proposals emerged trying to explain unexpectedly long coherence. According to one proposal, if each site within the complex feels its own environmental noise, the electron will not remain in any local minimum due to both quantum coherence and thermal environment, but proceed to the reaction site via quantum walks.[19][20][21] Another proposal is that the rate of quantum coherence and electron tunneling create an energy sink that moves the electron to the reaction site quickly.[22] Other work suggested that geometric symmetries in the complex may favor efficient energy transfer to the reaction center, mirroring perfect state transfer in quantum networks.[23] Furthermore, experiments with artificial dye molecules cast doubts on the interpretation that quantum effects last any longer than one hundred femtoseconds.[24]

In 2017, the first control experiment with the original FMO protein under ambient conditions confirmed that electronic quantum effects are washed out within 60 femtoseconds, while the overall exciton transfer takes a time on the order of a few picoseconds.[25] In 2020 a review based on a wide collection of control experiments and theory concluded that the proposed quantum effects as long lived electronic coherences in the FMO system does not hold.[26] Instead, research investigating transport dynamics suggests that interactions between electronic and vibrational modes of excitation in FMO complexes require a semi-classical, semi-quantum explanation for the transfer of exciton energy. In other words, while quantum coherence dominates in the short-term, a classical description is most accurate to describe long-term behavior of the excitons.[27]

Another process in photosynthesis that has almost 100% efficiency is charge transfer, again suggesting that quantum mechanical phenomena are at play.[18] In 1966, a study on the photosynthetic bacteria Chromatium found that at temperatures below 100 K, cytochrome oxidation is temperature-independent, slow (on the order of milliseconds), and very low in activation energy. The authors, Don DeVault and Britton Chase, postulated that these characteristics of electron transfer are indicative of quantum tunneling, whereby electrons penetrate a potential barrier despite possessing less energy than is classically necessary.[28]

Seth Lloyd is also notable for his contributions to this area of research.

DNA mutationEdit

Deoxyribonucleic acid, DNA, acts as the instructions for making proteins throughout the body. It consists of 4 nucleotides guanine, thymine, cytosine, and adenine.[29] The order of these nucleotides gives the “recipe” for the different proteins.

Whenever a cell reproduces, it must copy these strands of DNA. However, sometimes throughout the process of copying the strand of DNA a mutation, or an error in the DNA code, can occur. A theory for the reasoning behind DNA mutation is explained in the Lowdin DNA mutation model.[30] In this model, a nucleotide may change its form through a process of quantum tunneling.[31] Because of this, the changed nucleotide will lose its ability to pair with its original base pair and consequently changing the structure and order of the DNA strand.

Exposure to ultraviolet lights and other types of radiation can cause DNA mutation and damage. The radiations also can modify the bonds along the DNA strand in the pyrimidines and cause them to bond with themselves creating a dimer.[32]

In many prokaryotes and plants, these bonds are repaired to their original form by a DNA repair enzyme photolyase. As its prefix implies, photolyase is reliant on light in order to repair the strand. Photolyase works with its cofactor FADH, flavin adenine dinucleotide, while repairing the DNA. Photolyase is excited by visible light and transfers an electron to the cofactor FADH-. FADH- now in the possession of an extra electron gives the electron to the dimer to break the bond and repair the DNA. This transfer of the electron is done through the tunneling of the electron from the FADH to the dimer. Although the range of the tunneling is much larger than feasible in a vacuum, the tunneling in this scenario is said to be “superexchange-mediated tunneling,” and is possible due to the protein's ability to boost the tunneling rates of the electron.[30]

Vibration theory of olfactionEdit

Olfaction, the sense of smell, can be broken down into two parts; the reception and detection of a chemical, and how that detection is sent to and processed by the brain. This process of detecting an odorant is still under question. One theory named the “shape theory of olfaction” suggests that certain olfactory receptors are triggered by certain shapes of chemicals and those receptors send a specific message to the brain.[33] Another theory (based on quantum phenomena) suggests that the olfactory receptors detect the vibration of the molecules that reach them and the “smell” is due to different vibrational frequencies, this theory is aptly called the “vibration theory of olfaction.”

The vibration theory of olfaction, created in 1938 by Malcolm Dyson[34] but reinvigorated by Luca Turin in 1996,[35] proposes that the mechanism for the sense of smell is due to G-protein receptors that detect molecular vibrations due to inelastic electron tunneling, tunneling where the electron loses energy, across molecules.[35] In this process a molecule would fill a binding site with a G-protein receptor. After the binding of the chemical to the receptor, the chemical would then act as a bridge allowing for the electron to be transferred through the protein. As the electron transfers across what would otherwise have been a barrier, it loses energy due to the vibration of the newly-bound molecule to the receptor. This results in the ability to smell the molecule.[35][3]

While the vibration theory has some experimental proof of concept,[36][37] there have been multiple controversial results in experiments. In some experiments, animals are able to distinguish smells between molecules of different frequencies and same structure,[38] while other experiments show that people are unaware of distinguishing smells due to distinct molecular frequencies.[39] However, it has not been disproven, and has even been shown to be an effect in olfaction of animals other than humans such as flies, bees, and fish.[citation needed]


Vision relies on quantized energy in order to convert light signals to an action potential in a process called phototransduction. In phototransduction, a photon interacts with a chromophore in a light receptor. The chromophore absorbs the photon and undergoes photoisomerization. This change in structure induces a change in the structure of the photo receptor and resulting signal transduction pathways lead to a visual signal. However, the photoisomerization reaction occurs at a rapid rate, in under 200 femtoseconds,[40] with high yield. Models suggest the use of quantum effects in shaping the ground state and excited state potentials in order to achieve this efficiency.[41]

Quantum vision implicationsEdit

Experiments have shown that the sensors in the retina of human eye is sensitive enough to detect a single photon.[42] Single photon detection could lead to multiple different technologies. One area of development is in quantum communication and cryptography. The idea is to use a biometric system to measure the eye using only a small number of points across the retina with random flashes of photons that “read” the retina and identify the individual.[43] This biometric system would only allow a certain individual with a specific retinal map to decode the message. This message can not be decoded by anyone else unless the eavesdropper were to guess the proper map or could read the retina of the intended recipient of the message.[44]

Enzymatic activity (quantum biochemistry)Edit

Enzymes have been postulated to use quantum tunneling in order to transfer electrons from one place to another in electron transport chains.[45][46][47] It is possible that protein quaternary architectures may have adapted to enable sustained quantum entanglement and coherence, which are two of the limiting factors for quantum tunneling in biological entities.[48] These architectures might account for a greater percentage of quantum energy transfer, which occurs through electron transport and proton tunneling (usually in the form of hydrogen ions, H+).[49][50] Tunneling refers to the ability of a subatomic particle to travel through potential energy barriers.[51] This ability is due, in part, to the principle of complementarity, which holds that certain substances have pairs of properties that cannot be measured separately without changing the outcome of measurement. Particles, such as electrons and protons, have wave-particle duality; they can pass through energy barriers due to their wave characteristics without violating the laws of physics. In order to quantify how quantum tunneling is used in many enzymatic activities, many biophysicists utilize the observation of hydrogen ions. When hydrogen ions are transferred, this is seen as a staple in an organelle's primary energy processing network; in other words, quantum effects are most usually at work in proton distribution sites at distances on the order of fractional nanometers (~0.1 nm).[52][53] In physics, a semiclassical (SC) approach is most useful in defining this process because of the transfer from quantum elements (e.g. particles) to macroscopic phenomena (e.g. biochemicals). Aside from hydrogen tunneling, studies also show that electron transfers between redox centers through quantum tunneling plays an important role in enzymatic activity of photosynthesis and cellular respiration (see also Mitochondria section below).[54][55] For example, electron tunneling on the order of 15–30 Å contributes to redox reactions in cellular respiration enzymes, such as complexes I, III, and IV in mitochondria.[56][57] Without quantum tunneling, organisms would not be able to convert energy quickly enough to sustain growth.[30] Quantum tunneling actually acts as a shortcut for particle transfer; according to quantum mathematics, a particle's jump from in front of a barrier to the other side of a barrier occurs faster than if the barrier had never been there in the first place. (For more on the technicality of this, see Hartman effect.)


Organelles, such as mitochondria, are thought to utilize quantum tunneling in order to translate intracellular energy.[58] Traditionally, mitochondria are known to generate most of the cell's energy in the form of chemical ATP. Mitochondria conversion of biomass into chemical ATP is 60-70% efficient, which is superior than the classical regime of man-made engines.[59] To achieve chemical ATP, researchers have found that a preliminary stage before chemical conversion is necessary; this step, via the quantum tunneling of electrons and hydrogen ions (H+), requires a deeper look at the quantum physics that occurs within the organelle.[53]

Because tunneling is a quantum mechanism, it is important to understand how this process may occur for particle transfer in a biological system. Tunneling is largely dependent upon the shape and size of a potential barrier, relative to the incoming energy of a particle.[60] Because the incoming particle can be defined by a wave equation, its tunneling probability is dependent upon the potential barrier's shape in an exponential way, meaning that if the barrier is akin to a very wide chasm, the incoming particle's probability to tunnel will decrease. The potential barrier, in some sense, can come in the form of an actual biomaterial barrier. Mitochondria are encompassed by a membrane structure that is akin to the cellular membrane, on the order of ~75 Å (~7.5 nm) thick.[59] The inner membrane of a mitochondria must be overcome to permit signals (in the form of electrons, protons, H+) to transfer from the site of emittance (internal to the mitochondria) and the site of acceptance (i.e. the electron transport chain proteins).[61] In order to transfer particles, the membrane of the mitochondria must have the correct density of phospholipids to conduct a relevant charge distribution that attracts the particle in question. For instance, for a greater density of phospholipids, the membrane contributes to a greater conductance of protons.[61]

For a more technical description, the following paragraph is useful. The form of the mitochondria is known as the matrix, with inner mitochondrial membranes (IMM) and inner membrane spaces (IMS), all housing various protein sites. Mitochondria produce ATP by the oxidation of hydrogen ions from carbohydrates and fats. This process utilizes electrons in an electron transport chain (ETP). The genealogy of electron transport proceeds as follows: Electrons from NADH are transferred to NADH dehydrogenase (complex I protein), which is located in the IMM.[62] Electrons from complex I are transferred to coenzyme Q to make CoQH2; next, electrons flow to cytochrome-containing IMM protein (complex III), which further pushes electrons to cytochrome c, where electrons flow to complex IV; complex IV is the final IMM protein complex of the ETC respiratory chain.[62] This final protein allows electrons to reduce oxygen from an O2 molecule to a single O, so that it can bind to the hydrogen ions to produce H2O. The energy produced from the movement of electrons through the ETC induces proton movement (known as H+ pumping) out of the mitochondria matrix into the IMS.[57] Because any charge movement creates a magnetic field, the IMS now houses a capacitance across the matrix. The capacitance is akin to potential energy, or what is known as a potential barrier. This potential energy guides ATP synthesis via complex V (ATP synthase), which conflates ADP with another P to create ATP by pushing protons (H+) back into the matrix (this process is known as oxidative phosphorylation). Finally, the outer mitochondrial membrane (OMM) houses a voltage-dependent anion channel called the VDAC.[62] This site is important for converting energy signals into electro-chemical outputs for ATP transfer.


Magnetoreception refers to the ability of animals to navigate using the inclination of the magnetic field of the earth.[63] A possible explanation for magnetoreception is the entangled radical pair mechanism.[64][65] The radical-pair mechanism is well-established in spin chemistry,[66][67][68] and was speculated to apply to magnetoreception in 1978 by Schulten et al.. The ratio between singlet and triplet pairs is changed by the interaction of entangled electron pairs with the magnetic field of the earth.[69] In 2000, cryptochrome was proposed as the "magnetic molecule" that could harbor magnetically sensitive radical-pairs. Cryptochrome, a flavoprotein found in the eyes of European robins and other animal species, is the only protein known to form photoinduced radical-pairs in animals.[63] When it interacts with light particles, cryptochrome goes through a redox reaction, which yields radical pairs both during the photo-reduction and the oxidation. The function of cryptochrome is diverse across species, however, the photoinduction of radical-pairs occurs by exposure to blue light, which excites an electron in a chromophore.[69] Magnetoreception is also possible in the dark, so the mechanism must rely more on the radical pairs generated during light-independent oxidation.

Experiments in the lab support the basic theory that radical-pair electrons can be significantly influenced by very weak magnetic fields, i.e. merely the direction of weak magnetic fields can affect radical-pair's reactivity and therefore can "catalyze" the formation of chemical products. Whether this mechanism applies to magnetoreception and/or quantum biology, that is, whether earth's magnetic field "catalyzes" the formation of biochemical products by the aid of radical-pairs, is undetermined for two reasons. The first is that radical-pairs may need not be entangled, the key quantum feature of the radical-pair mechanism, to play a part in these processes. There are entangled and non-entangled radical-pairs. However, researchers found evidence for the radical-pair mechanism of magnetoreception when European robins, cockroaches, and garden warblers, could no longer navigate when exposed to a radio frequency that obstructs magnetic fields[63] and radical-pair chemistry. To empirically suggest the involvement of entanglement, an experiment would need to be devised that could disturb entangled radical-pairs without disturbing other radical-pairs, or vice versa, which would first need to be demonstrated in a laboratory setting before being applied to in vivo radical-pairs.

Other biological applicationsEdit

Other examples of quantum phenomena in biological systems include the conversion of chemical energy into motion[70] and brownian motors in many cellular processes.[71]

Biological Homing.Edit

Biological homing is a theory that there is a long-range quantum mechanical force between complimentary pairs of biological molecules (60 Meggs WJ.  Biological homing: Hypothesis for a quantum effect that leads to the existence of life.  Medical Hypotheses 1998;51:503.506.

). Examples of complimentary pairs of biological molecules are enzymes and substrates, hormones and receptors, and antibodies and surface proteins on micro-organisms. A demonstration has been given if complimentary molecules have identical charge distributions, but with positive and negative charges reversed on the two molecules, the probability of quantum interaction is proportional to the square of the number of charges.


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