Protein arginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene.[5][6]

PRMT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRMT2, HRMT1L1, protein arginine methyltransferase 2
External IDsOMIM: 601961 MGI: 1316652 HomoloGene: 55587 GeneCards: PRMT2
EC number2.1.1.321
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077638
NM_133182
NM_001302965

RefSeq (protein)

n/a

Location (UCSC)Chr 21: 46.64 – 46.67 MbChr 10: 76.04 – 76.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Functions edit

The enzyme methylates final nitrogen atom of arginine residue in some proteins. It transfers two methyl groups from S-adenosyl-L-methionine.

Interactions edit

PRMT2 has been shown to interact with Estrogen receptor alpha[7] and HNRPUL1.[8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160310 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020230 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF (Jun 1998). "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)". Genomics. 48 (3): 330–40. doi:10.1006/geno.1997.5190. PMID 9545638.
  6. ^ "Entrez Gene: PRMT2 protein arginine methyltransferase 2".
  7. ^ Qi, Chao; Chang Jeffrey; Zhu Yiwei; Yeldandi Anjana V; Rao Sambasiva M; Zhu Yi-Jun (Aug 2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. 277 (32). United States: 28624–30. doi:10.1074/jbc.M201053200. ISSN 0021-9258. PMID 12039952.
  8. ^ Kzhyshkowska, J; Schütt H; Liss M; Kremmer E; Stauber R; Wolf H; Dobner T (Sep 2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. 358 (Pt 2). England: 305–14. doi:10.1042/0264-6021:3580305. ISSN 0264-6021. PMC 1222062. PMID 11513728.

Further reading edit