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Premnaspirodiene oxygenase

Premnaspirodiene oxygenase (EC 1.14.13.121, HPO, Hyoscymus muticus premnaspirodiene oxygenase) is an enzyme with systematic name (-)-vetispiradiene,NADPH:oxygen 2alpha-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

Premnaspirodiene oxygenase
Identifiers
EC no.1.14.13.121
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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NCBIproteins
(-)-vetispiradiene + 2 NADPH + 2 H+ + 2 O2 solavetivone + 2 NADP+ + 3 H2O (overall reaction)
(1a) (-)-vetispiradiene + NADPH + H+ + O2 solavetivol + NADP+ + H2O
(1b) solavetivol + NADPH + H+ + O2 solavetivone + NADP+ + 2 H2O

Premnaspirodiene oxygenase heme-thiolate protein (P-450).

References edit

  1. ^ Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J (October 2007). "Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates". The Journal of Biological Chemistry. 282 (43): 31744–54. doi:10.1074/jbc.M703378200. PMC 2695360. PMID 17715131.

External links edit

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