In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe. The PFC contains Brodmann areas 8, 9, 10, 11, 12, 13, 14, 24, 25, 32, 44, 45, 46, and 47.
|Part of||Frontal lobe|
|Components||Superior frontal gyrus
Middle frontal gyrus
Inferior frontal gyrus
|Vein||Superior sagittal sinus|
|NeuroLex ID||Prefrontal cortex|
|Anatomical terms of neuroanatomy|
Many authors have indicated an integral link between a person's will to live, personality, and the functions of the prefrontal cortex. This brain region has been implicated in planning complex cognitive behavior, personality expression, decision making, and moderating social behavior. The basic activity of this brain region is considered to be orchestration of thoughts and actions in accordance with internal goals.
The most typical psychological term for functions carried out by the prefrontal cortex area is executive function. Executive function relates to abilities to differentiate among conflicting thoughts, determine good and bad, better and best, same and different, future consequences of current activities, working toward a defined goal, prediction of outcomes, expectation based on actions, and social "control" (the ability to suppress urges that, if not suppressed, could lead to socially unacceptable outcomes).
Frontal cortex supports concrete rule learning. More anterior regions along the rostro-caudal axis of frontal cortex support rule learning at higher levels of abstraction.
This section needs to be updated.(March 2017)
There are three possible ways to define the prefrontal cortex:
- as the granular frontal cortex
- as the projection zone of the medial dorsal nucleus of the thalamus
- as that part of the frontal cortex whose electrical stimulation does not evoke movements
The prefrontal cortex has been defined based on cytoarchitectonics by the presence of a cortical granular layer IV. It is not entirely clear who first used this criterion. Many of the early cytoarchitectonic researchers restricted the use of the term prefrontal to a much smaller region of cortex including the gyrus rectus and the gyrus rostralis (Campbell, 1905; G. E. Smith, 1907; Brodmann, 1909; von Economo and Koskinas, 1925). In 1935, however, Jacobsen used the term prefrontal to distinguish granular prefrontal areas from agranular motor and premotor areas. In terms of Brodmann areas, the prefrontal cortex traditionally includes areas 8, 9, 10, 11, 12, 13, 14, 24, 25, 32, 44, 45, 46, and 47; however, not all of these areas are strictly granular – 44 is dysgranular, caudal 11 and orbital 47 are agranular. The main problem with this definition is that it works well only in primates but not in nonprimates, as the latter lack a granular layer IV.
To define the prefrontal cortex as the projection zone of the mediodorsal nucleus of the thalamus builds on the work of Rose and Woolsey who showed that this nucleus projects to anterior and ventral parts of the brain in nonprimates. Rose and Woolsey however termed this projection zone "orbitofrontal." It seems to have been Akert, who in 1964 for the first time explicitly suggested that this criterion could be used to define homologues of the prefrontal cortex in primates and nonprimates. This allowed the establishment of homologies despite the lack of a granular frontal cortex in nonprimates. The projection zone definition is still widely accepted today (e.g. Fuster), although its usefulness has been questioned. Modern tract tracing studies have shown that projections of the mediodorsal nucleus of the thalamus are not restricted to the granular frontal cortex in primates. As a result, it was suggested to define the prefrontal cortex as the region of cortex that has stronger reciprocal connections with the mediodorsal nucleus than with any other thalamic nucleus. Uylings et al. acknowledge, however, that even with the application of this criterion it might be rather difficult to unequivocally define the prefrontal cortex..
A third definition of the prefrontal cortex is the area of frontal cortex whose electrical stimulation does not lead to observable movements. For example, in 1890 David Ferrier used the term in this sense. One complication with this definition is that the electrically "silent" frontal cortex includes both granular and non-granular areas.
The table below shows different ways to subdivide parts of the prefrontal cortex based upon Brodmann areas.
- The medial prefrontal cortex (mPFC) is composed of granular cortical areas (medial areas 9 and 10) and agranular regions (areas 24, 25, and 32) which encompasses the anterior cingulate cortex (area 24), infralimbic cortex (area 25), and prelimbic cortex (area 32).
- The orbitofrontal cortex is composed of granular cortical areas (area 11) and mixed granular and agranular regions (areas 13 and 14).
- The ventrolateral prefrontal cortex is composed of areas 12, 44, 45, and 47.
- The dorsolateral prefrontal cortex is composed of the lateral part of area 9 and all of area 46.
- The caudal prefrontal cortex is composed of area 8, including the frontal eye fields.
The prefrontal cortex is highly interconnected with much of the brain, including extensive connections with other cortical, subcortical and brain stem sites. The dorsal prefrontal cortex is especially interconnected with brain regions involved with attention, cognition and action, while the ventral prefrontal cortex interconnects with brain regions involved with emotion. The prefrontal cortex also receives inputs from the brainstem arousal systems, and its function is particularly dependent on its neurochemical environment. Thus, there is coordination between our state of arousal and our mental state.
The medial prefrontal cortex has been implicated in the generation of slow-wave sleep (SWS), and prefrontal atrophy has been linked to decreases in SWS. Prefrontal atrophy occurs naturally as individuals age, and it has been demonstrated that older adults experience impairments in memory consolidation as their medial prefrontal cortices degrade. In monkeys, significant atrophy has been found as a result of neuroleptic or antipsychotic psychiatric medication. In older adults, instead of being transferred and stored in the neocortex during SWS, memories start to remain in the hippocampus where they were encoded, as evidenced by increased hippocampal activation compared to younger adults during recall tasks when subjects learned word associations, slept, and then were asked to recall the learned words.
The original studies of Fuster and of Goldman-Rakic emphasized the fundamental ability of the prefrontal cortex to represent information not currently in the environment, and the central role of this function in creating the "mental sketch pad". Goldman-Rakic spoke of how this representational knowledge was used to intelligently guide thought, action and emotion, including the inhibition of inappropriate thoughts, distractions, actions, and feelings. In this way, working memory can be seen as fundamental to attention and behavioral inhibition. Fuster speaks of how this prefrontal ability allows the wedding of past to future, allowing both cross-temporal and cross-modal associations in the creation of goal-directed, perception-action cycles. This ability to represent underlies all other higher executive functions.
Shimamura proposed Dynamic Filtering Theory to describe the role of the prefrontal cortex in executive functions. The prefrontal cortex is presumed to act as a high-level gating or filtering mechanism that enhances goal-directed activations and inhibits irrelevant activations. This filtering mechanism enables executive control at various levels of processing, including selecting, maintaining, updating, and rerouting activations. It has also been used to explain emotional regulation.
Miller and Cohen proposed an Integrative Theory of Prefrontal Cortex Function, that arises from the original work of Goldman-Rakic and Fuster. The two theorize that “cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represents goals and means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task”. In essence, the two theorize that the prefrontal cortex guides the inputs and connections, which allows for cognitive control of our actions.
The prefrontal cortex is of significant importance when top-down processing is needed. Top-down processing by definition is when behavior is guided by internal states or intentions. According to the two, “The PFC is critical in situations when the mappings between sensory inputs, thoughts, and actions either are weakly established relative to other existing ones or are rapidly changing”. An example of this can be portrayed in the Wisconsin Card Sorting Test (WCST). Subjects engaging in this task are instructed to sort cards according to the shape, color, or number of symbols appearing on them. The thought is that any given card can be associated with a number of actions and no single stimulus-response mapping will work. Human subjects with PFC damage are able to sort the card in the initial simple tasks, but unable to do so as the rules of classification change.
Miller and Cohen conclude that the implications of their theory can explain how much of a role the PFC has in guiding control of cognitive actions. In the researchers' own words, they claim that, “depending on their target of influence, representations in the PFC can function variously as attentional templates, rules, or goals by providing top-down bias signals to other parts of the brain that guide the flow of activity along the pathways needed to perform a task”.
Experimental data indicate a role for the prefrontal cortex in mediating normal sleep physiology, dreaming and sleep-deprivation phenomena.
When analyzing and thinking about attributes of other individuals, the medial prefrontal cortex is activated. However, it is not activated when contemplating about the characteristics of inanimate objects.
Studies using fMRI have shown that the medial prefrontal cortex (mPFC), specifically the anterior medial prefrontal cortex (amPFC), may modulate mimicry behavior. Neuroscientists are suggesting that social priming influences activity and processing in the amPFC, and that this area of the prefrontal cortex modulates mimicry responses and behavior.
As of recent, researchers have used neuroimaging techniques to find that along with the basal ganglia, the prefrontal cortex is involved with learning exemplars, which is part of the exemplar theory, one of the three main ways our mind categorizes things. The exemplar theory states that we categorize judgements by comparing it to a similar past experience within our stored memories.
A 2014 meta-analysis by Professor Nicole P.Yuan from the University of Arizona found that larger prefrontal cortex volume and greater PFC cortical thickness were associated with better executive performance.
Attention and memoryEdit
A widely accepted theory regarding the function of the brain's prefrontal cortex is that it serves as a store of short-term memory. This idea was first formulated by Jacobsen, who reported in 1936 that damage to the primate prefrontal cortex caused short-term memory deficits. Karl Pribram and colleagues (1952) identified the part of the prefrontal cortex responsible for this deficit as area 46, also known as the dorsolateral prefrontal cortex (dlPFC). More recently, Goldman-Rakic and colleagues (1993) evoked short-term memory loss in localized regions of space by temporary inactivation of portions of the dlPFC. Once the concept of working memory (see also Baddeley's model of working memory) was established in contemporary neuroscience by Baddeley (1986), these neuropsychological findings contributed to the theory that the prefrontal cortex implements working memory and, in some extreme formulations, only working memory. In the 1990s this theory developed a wide following, and it became the predominant theory of PF function, especially for nonhuman primates. The concept of working memory used by proponents of this theory focused mostly on the short-term maintenance of information, and rather less on the manipulation or monitoring of such information or on the use of that information for decisions. Consistent with the idea that the prefrontal cortex functions predominantly in maintenance memory, delay-period activity in the PF has often been interpreted as a memory trace. (The phrase "delay-period activity" applies to neuronal activity that follows the transient presentation of an instruction cue and persists until a subsequent "go" or "trigger" signal.)
To explore alternative interpretations of delay-period activity in the prefrontal cortex, Lebedev et al. (2004) investigated the discharge rates of single prefrontal neurons as monkeys attended to a stimulus marking one location while remembering a different, unmarked location. Both locations served as potential targets of a saccadic eye movement. Although the task made intensive demands on short-term memory, the largest proportion of prefrontal neurons represented attended locations, not remembered ones. These findings showed that short-term memory functions cannot account for all, or even most, delay-period activity in the part of the prefrontal cortex explored. The authors suggested that prefrontal activity during the delay-period contributes more to the process of attentional selection (and selective attention) than to memory storage.
In the last few decades, brain imaging systems have been used to determine brain region volumes and nerve linkages. Several studies have indicated that reduced volume and interconnections of the frontal lobes with other brain regions is observed in patients diagnosed with mental disorders and prescribed potent antipsychotics; those subjected to repeated stressors; suicides; those incarcerated; criminals; sociopaths; those affected by lead poisoning; and daily male cannabis users (only 13 people were tested). It is believed that at least some of the human abilities to feel guilt or remorse, and to interpret reality, are dependent on a well-functioning prefrontal cortex. It is also widely believed that the size and number of connections in the prefrontal cortex relates directly to sentience, as the prefrontal cortex in humans occupies a far larger percentage of the brain than in any other animal. And it is theorized that, as the brain has tripled in size over five million years of human evolution, the prefrontal cortex has increased in size sixfold.
A review on executive functions in healthy exercising individuals noted that the left and right halves of the prefrontal cortex, which is divided by the medial longitudinal fissure, appear to become more interconnected in response to consistent aerobic exercise. Two reviews of structural neuroimaging research indicate that marked improvements in prefrontal and hippocampal gray matter volume occur in healthy adults that engage in medium intensity exercise for several months.
A functional neuroimaging review of meditation-based practices suggested that practicing mindfulness enhances prefrontal activation, which was noted to be correlated with increased well-being and reduced anxiety; however, the review noted the need for cohort studies in future research to better establish this.
Perhaps the seminal case in prefrontal cortex function is that of Phineas Gage, whose left frontal lobe was destroyed when a large iron rod was driven through his head in an 1848 accident. The standard presentation (e.g.) is that, although Gage retained normal memory, speech and motor skills, his personality changed radically: He became irritable, quick-tempered, and impatient—characteristics he did not previously display — so that friends described him as "no longer Gage"; and, whereas he had previously been a capable and efficient worker, afterward he was unable to complete tasks. However, careful analysis of primary evidence shows that descriptions of Gage's psychological changes are usually exaggerated when held against the description given by Gage's doctor, the most striking feature being that changes described years after Gage's death are far more dramatic than anything reported while he was alive.
Subsequent studies on patients with prefrontal injuries have shown that the patients verbalized what the most appropriate social responses would be under certain circumstances. Yet, when actually performing, they instead pursued behavior aimed at immediate gratification, despite knowing the longer-term results would be self-defeating.
The interpretation of this data indicates that not only are skills of comparison and understanding of eventual outcomes harbored in the prefrontal cortex but the prefrontal cortex (when functioning correctly) controls the mental option to delay immediate gratification for a better or more rewarding longer-term gratification result. This ability to wait for a reward is one of the key pieces that define optimal executive function of the human brain.
There is much current research devoted to understanding the role of the prefrontal cortex in neurological disorders. Many disorders, such as schizophrenia, bipolar disorder, and ADHD, have been related to dysfunction of the prefrontal cortex, and thus this area of the brain offers the potential for new treatments of these conditions. Clinical trials have begun on certain drugs that have been shown to improve prefrontal cortex function, including guanfacine, which acts through the alpha-2A adrenergic receptor. A downstream target of this drug, the HCN channel, is one of the most recent areas of exploration in prefrontal cortex pharmacology.
The term "prefrontal" as describing a part of the brain appears to have been introduced by Richard Owen in 1868. For him, the prefrontal area was restricted to the anterior-most part of the frontal lobe (approximately corresponding to the frontal pole). It has been hypothesized that his choice of the term was based on the prefrontal bone present in most amphibians and reptiles.
Animation. Prefrontal cortex of left cerebral hemisphere (shown in red).
- Elisabeth Murray, Steven Wise, Kim Graham (2016). "Chapter 1: The History of Memory Systems". The Evolution of Memory Systems: Ancestors, Anatomy, and Adaptations (1st ed.). Oxford University Press. pp. 22–24. ISBN 9780191509957. Retrieved 12 March 2017.
- DeYoung CG, Hirsh JB, Shane MS, Papademetris X, Rajeevan N, Gray JR (June 2010). "Testing predictions from personality neuroscience. Brain structure and the big five". Psychological Science. 21 (6): 820–8. doi:10.1177/0956797610370159. PMC . PMID 20435951.
- Yang Y, Raine A (November 2009). "Prefrontal structural and functional brain imaging findings in antisocial, violent, and psychopathic individuals: a meta-analysis". Psychiatry Research. 174 (2): 81–8. doi:10.1016/j.pscychresns.2009.03.012. PMC . PMID 19833485.
- Miller EK, Freedman DJ, Wallis JD (August 2002). "The prefrontal cortex: categories, concepts and cognition". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 357 (1424): 1123–36. doi:10.1098/rstb.2002.1099. PMC . PMID 12217179.
- Badre D, Kayser AS, D'Esposito M (April 2010). "Frontal cortex and the discovery of abstract action rules". Neuron. 66 (2): 315–26. doi:10.1016/j.neuron.2010.03.025. PMC . PMID 20435006.
- Finger, Stanley (1994). Origins of neuroscience: a history of explorations into brain function. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-514694-8.[page needed]
- Preuss TM (1995). "Do rats have prefrontal cortex? The rose-woolsey-akert program reconsidered". Journal of Cognitive Neuroscience. 7 (1): 1–24. doi:10.1162/jocn.19188.8.131.52. PMID 23961750.
- Uylings HB, Groenewegen HJ, Kolb B (November 2003). "Do rats have a prefrontal cortex?". Behavioural Brain Research. 146 (1–2): 3–17. doi:10.1016/j.bbr.2003.09.028. PMID 14643455.
- Rose JE, Woolsey CN (1948). "The orbitofrontal cortex and its connections with the mediodorsal nucleus in rabbit, sheep and cat". Research Publications - Association for Research in Nervous and Mental Disease. 27: 210–32. PMID 18106857.
- Preuss TM, Goldman-Rakic PS (August 1991). "Myelo- and cytoarchitecture of the granular frontal cortex and surrounding regions in the strepsirhine primate Galago and the anthropoid primate Macaca". The Journal of Comparative Neurology. 310 (4): 429–74. doi:10.1002/cne.903100402. PMID 1939732.
- Fuster, Joaquin M. (2008). The Prefrontal Cortex (4th ed.). Boston: Academic Press. ISBN 0-12-373644-7.[page needed]
- Markowitsch HJ; Pritzel, M (1979). "The prefrontal cortex: Projection area of the thalamic mediodorsal nucleus?". Physiological Psychology. 7 (1): 1–6. doi:10.3758/bf03326611. Retrieved 2 April 2011.
- Ferrier D (1890). "The Croonian lectures on cerebral localisation. Lecture II". The British Medical Journal. 1 (1537): 1349–1355. doi:10.1136/bmj.1.1537.1349. PMC . PMID 20753055.
- Alvarez JA, Emory E (March 2006). "Executive function and the frontal lobes: a meta-analytic review". Neuropsychology Review. 16 (1): 17–42. doi:10.1007/s11065-006-9002-x. PMID 16794878.
- Goldman-Rakic PS (1988). "Topography of cognition: parallel distributed networks in primate association cortex". Annual Review of Neuroscience. 11: 137–56. doi:10.1146/annurev.ne.11.030188.001033. PMID 3284439.
- Price JL (June 1999). "Prefrontal cortical networks related to visceral function and mood". Annals of the New York Academy of Sciences. 877: 383–96. doi:10.1111/j.1749-6632.1999.tb09278.x. PMID 10415660.
- Robbins TW, Arnsten AF (2009). "The neuropsychopharmacology of fronto-executive function: monoaminergic modulation". Annual Review of Neuroscience. 32: 267–87. doi:10.1146/annurev.neuro.051508.135535. PMC . PMID 19555290.
- Arnsten AF, Paspalas CD, Gamo NJ, Yang Y, Wang M (August 2010). "Dynamic Network Connectivity: A new form of neuroplasticity". Trends in Cognitive Sciences. 14 (8): 365–75. doi:10.1016/j.tics.2010.05.003. PMC . PMID 20554470.
- Mander BA, Rao V, Lu B, et al. (March 2013). "Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging". Nature Neuroscience. 16 (3): 357–64. doi:10.1038/nn.3324. PMC . PMID 23354332.
- Dorph-Petersen KA, Pierri JN, Perel JM, Sun Z, Sampson AR, Lewis DA (September 2005). "The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: a comparison of haloperidol and olanzapine in macaque monkeys". Neuropsychopharmacology. 30 (9): 1649–61. doi:10.1038/sj.npp.1300710. PMID 15756305.
- Goldman-Rakic PS (October 1996). "The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 351 (1346): 1445–53. doi:10.1098/rstb.1996.0129. JSTOR 3069191. PMID 8941956.
- Fuster JM, Bodner M, Kroger JK (May 2000). "Cross-modal and cross-temporal association in neurons of frontal cortex". Nature. 405 (6784): 347–51. doi:10.1038/35012613. PMID 10830963.
- Shimamura AP (2000). "The role of the prefrontal cortex in dynamic filtering". Psychobiology. 28: 207–218. doi:10.3758/BF03331979.
- Miller EK, Cohen JD (2001). "An integrative theory of prefrontal cortex function". Annu Rev Neurosci. 24: 167–202. doi:10.1146/annurev.neuro.24.1.167. PMID 11283309.
- Muzur A, Pace-Schott EF, Hobson JA (November 2002). "The prefrontal cortex in sleep". Trends in Cognitive Sciences. 6 (11): 475–481. doi:10.1016/S1364-6613(02)01992-7. PMID 12457899.
- Mitchell JP, Heatherton TF, Macrae CN (November 2002). "Distinct neural systems subserve person and object knowledge". Proceedings of the National Academy of Sciences of the United States of America. 99 (23): 15238–43. doi:10.1073/pnas.232395699. PMC . PMID 12417766.
- Wang, Yin; Hamilton, Antonia F. de C. "Anterior medial prefrontal cortex implements social priming of mimicry". Social Cognitive and Affective Neuroscience. 10 (4): 486–493. doi:10.1093/scan/nsu076. PMC . PMID 25009194.
- Schacter, Daniel L., Daniel Todd Gilbert, and Daniel M. Wegner. Psychology. 2nd ed, pages 364-366 New York, NY: Worth Publishers, 2011. Print.
- Yuan, Peng; Raz, Naftali (2014-05-01). "Prefrontal cortex and executive functions in healthy adults: a meta-analysis of structural neuroimaging studies". Neuroscience and Biobehavioral Reviews. 42: 180–192. doi:10.1016/j.neubiorev.2014.02.005. ISSN 1873-7528. PMC . PMID 24568942.
- Lebedev, M. A.; Messinger, A.; Kralik, J. D.; Wise, S. P. (2004). "Representation of Attended Versus Remembered Locations in Prefrontal Cortex". PLoS Biology. 2 (11): e365. doi:10.1371/journal.pbio.0020365. PMC . PMID 15510225.
- Jacobsen C.F. (1936) Studies of cerebral function in primates. I. The functions of the frontal associations areas in monkeys. Comp Psychol Monogr 13: 3–60.
- Pribram, K. H.; Mishkin, M.; Rosvold, H. E.; Kaplan, S. J. (1952). "Effects on delayed-response performance of lesions of dorsolateral and ventromedial frontal cortex of baboons". Journal of comparative and physiological psychology. 45 (6): 565–575. doi:10.1037/h0061240. PMID 13000029.
- Funahashi, S.; Bruce, C. J.; Goldman-Rakic, P. S. (1993). "Dorsolateral prefrontal lesions and oculomotor delayed-response performance: Evidence for mnemonic "scotomas"". The Journal of Neuroscience. 13 (4): 1479–1497. PMID 8463830.
- Baddeley A. (1986) Working memory. Oxford: Oxford University Press. p.289
- Liston C, et al. (2006). "Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting". J Neurosci. 26 (30): 7870–4. doi:10.1523/JNEUROSCI.1184-06.2006. PMID 16870732.
- Rajkowska G (1997). "Morphometric methods for studying the prefrontal cortex in suicide victims and psychiatric patients". Ann N Y Acad Sci. 836: 253–68. doi:10.1111/j.1749-6632.1997.tb52364.x. PMID 9616803.
- Cecil KM, Brubaker CJ, Adler CM, Dietrich KN, Altaye M, Egelhoff JC, Wessel S, Elangovan I, Hornung R, et al. (2008). Balmes J, ed. "Decreased brain volume in adults with childhood lead exposure". PLoS Med. 5 (5): e112. doi:10.1371/journal.pmed.0050112. PMC . PMID 18507499.
- Anderson SW; Bechara, A; Damasio, H; Tranel, D; Damasio, AR (1999). "Impairment of social and moral behavior related to early damage in human prefrontal cortex". Nature Neuroscience. 2 (11): 1032–7. doi:10.1038/14833. PMID 10526345.
- Schoenemann, P. Thomas; Thomas F. Budinger; Vincent M. Sarich; William S. Wang (25 April 2000). "Brain size does not predict general cognitive ability within families". Proceedings of the National Academy of Sciences of the United States of America. 97 (9): 4932–4937. doi:10.1073/pnas.97.9.4932. PMC . PMID 10781101.
- Ted Cascio, Dr Ted Cascio. "Ph.D. in Hollywood Ph.D". Ted Cascio is co-editor of House & Psychology. Psychology Today. Retrieved 2011-11-15.
- Guiney H, Machado L (February 2013). "Benefits of regular aerobic exercise for executive functioning in healthy populations". Psychon Bull Rev. 20 (1): 73–86. doi:10.3758/s13423-012-0345-4. PMID 23229442.
- Erickson KI, Leckie RL, Weinstein AM (September 2014). "Physical activity, fitness, and gray matter volume". Neurobiol. Aging. 35 Suppl 2: S20–528. doi:10.1016/j.neurobiolaging.2014.03.034. PMC . PMID 24952993. Retrieved 9 December 2014.
- Valkanova V, Eguia Rodriguez R, Ebmeier KP (June 2014). "Mind over matter—what do we know about neuroplasticity in adults?". Int Psychogeriatr. 26 (6): 891–909. doi:10.1017/S1041610213002482. PMID 24382194.
- Barnby JM, Bailey NW, Chambers R, Fitzgerald PB (2015). "How similar are the changes in neural activity resulting from mindfulness practice in contrast to spiritual practice?". Conscious Cogn. 36: 219–232. doi:10.1016/j.concog.2015.07.002. PMID 26172520.
This review examines the neuroimaging research that has focused on groups of meditating individuals, groups who engage in religious/spiritual practices, and research that has examined groups who perform both practices together, in an attempt to assess whether this may be the case. Differences in the balance of activity between the parietal and prefrontal cortical activation were found between the three groups. A relative prefrontal increase was reflective of mindfulness, which related to decreased anxiety and improved well-being. ... Future research can begin to use cohorts of participants in mindfulness studies which are controlled for using the variable of spirituality to explicitly examine how functional and structural similarities and differences may arise.
- Antonio Damasio, Descartes' Error. Penguin Putman Pub., 1994[page needed]
- Malcolm Macmillan, An Odd Kind of Fame: Stories of Phineas Gage (MIT Press, 2000), pp.116-119, 307-333, esp. pp.11,333.
- Macmillan, M. (2008). "Phineas Gage – Unravelling the myth". The Psychologist. British Psychological Society. 21 (9): 828–831.
- Wang M, Ramos BP, Paspalas CD, et al. (April 2007). "Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex". Cell. 129 (2): 397–410. doi:10.1016/j.cell.2007.03.015. PMID 17448997.
|Wikimedia Commons has media related to Prefrontal cortex.|