Postpartum depression

Postpartum depression (PPD), also called postnatal depression, is a type of mood disorder associated with childbirth, which can affect both sexes.[1][3] Symptoms may include extreme sadness, low energy, anxiety, crying episodes, irritability, and changes in sleeping or eating patterns.[1] Onset is typically between one week and one month following childbirth.[1] PPD can also negatively affect the newborn child.[4][2]

Postpartum depression
Other namesPostnatal depression
Postpartum Depression Venus.jpg
Postpartum Depression Venus, a representation of the loss and emptiness felt after childbirth that makes some women feel as if they are useless.
SpecialtyPsychiatry
SymptomsExtreme sadness, low energy, anxiety, changes in sleeping or eating patterns, crying episodes, irritability[1]
Usual onsetA week to a month after childbirth[1]
CausesUnclear[1]
Risk factorsPrior postpartum depression, bipolar disorder, family history of depression, psychological stress, complications of childbirth, lack of support, drug use disorder[1]
Diagnostic methodBased on symptoms[2]
Differential diagnosisBaby blues[1]
TreatmentCounselling, medications[2]
Frequency~15% of births[1]

While the exact cause of PPD is unclear, the cause is believed to be a combination of physical, emotional, genetic, and social factors.[1][5] These may include factors such as hormonal changes and sleep deprivation.[1][6] Risk factors include prior episodes of postpartum depression, bipolar disorder, a family history of depression, psychological stress, complications of childbirth, lack of support, or a drug use disorder.[1] Diagnosis is based on a person's symptoms.[2] While most women experience a brief period of worry or unhappiness after delivery, postpartum depression should be suspected when symptoms are severe and last over two weeks.[1]

Among those at risk, providing psychosocial support may be protective in preventing PPD.[7] This may include community support such as food, household chores, mother care, and companionship.[8] Treatment for PPD may include counseling or medications.[2] Types of counseling that have been found to be effective include interpersonal psychotherapy (IPT), cognitive behavioral therapy (CBT), and psychodynamic therapy.[2] Tentative evidence supports the use of selective serotonin reuptake inhibitors (SSRIs).[2]

Postpartum depression affects roughly 15% of women after childbirth.[9][10] Moreover, this mood disorder is estimated to affect 1% to 26% of new fathers.[3] Postpartum psychosis, a more severe form of postpartum mood disorder, occurs in about 1 to 2 per 1,000 women following childbirth.[11] Postpartum psychosis is one of the leading causes of the murder of children less than one year of age, which occurs in about 8 per 100,000 births in the United States.[12]

Signs and symptomsEdit

Symptoms of PPD can occur any time in the first year postpartum.[13] Typically, a diagnosis of postpartum depression is considered after signs and symptoms persist for at least two weeks.[14]

EmotionalEdit

  • Persistent sadness, anxiousness or "empty" mood[13]
  • Severe mood swings[14]
  • Frustration, irritability, restlessness, anger[13][15]
  • Feelings of hopelessness or helplessness[13]
  • Guilt, shame, worthlessness[13][15]
  • Low self-esteem[13]
  • Numbness, emptiness[13]
  • Exhaustion[13]
  • Inability to be comforted[13]
  • Trouble bonding with the baby[14]
  • Feeling inadequate in taking care of the baby[13][15]
  • Thoughts of self-harm or suicide[16]

BehaviouralEdit

NeurobiologyEdit

According to various fMRI studies, it's been concluded the significant differences in brain activity between mothers with postpartum depression and those without. While at rest, that is not cued by anything in the environment, mothers who suffer with PPD tend to have less activity in the left frontal lobe, and increased activity in the right frontal lobe when compared with healthy controls. They will also experience a decreased connectivity between vital brain structures, including the anterior cingulate cortex, dorsal lateral prefrontal cortex, amygdala, and hippocampus. These areas are important for empathy, memory, and emotion regulation, and may lead to depressive symptoms such as, decreased motivation toward caregiving. Brain activation differences between depressed, and nondepressed mothers is even more pronounced when stimulated by infant, and non-infant emotional cues. Depressed mothers show greater neural activity in the right amygdala toward non-infant emotional cues as well as reduced connectivity between the amygdala, and right insular cortex - a pattern, which is consistently found in those with depression and anxiety. Recent findings have also identified blunted activity in anterior cingulate cortex, striatum, orbitofrontal cortex, and insula in mothers with PPD when viewing images of their own infants.[18] According to a new research, it's concluded a progresses in identifying women with this type of illness, overall they classify this disorders as Heterogenous disorders.[19]

More robust studies on neural activation regarding PPD have been conducted with rodents than humans and has allowed for greater isolation of specific brain regions, neurotransmitters, hormones, and steroids.[18][20]

Onset and durationEdit

Postpartum depression onset usually begins between two weeks to a month after delivery.[21] A study done at an inner-city mental health clinic has shown that 50% of postpartum depressive episodes there began prior to delivery.[22] Therefore, in the DSM-5 postpartum depression is diagnosed under "depressive disorder with peripartum onset", in which "peripartum onset" is defined as anytime either during pregnancy or within the four weeks following delivery. PPD may last several months or even a year.[23] Postpartum depression can also occur in women who have suffered a miscarriage.[24] For fathers, several studies show that men experience the highest levels of postpartum depression between 3–6 months postpartum.[25]

Parent-infant relationshipEdit

Postpartum depression can interfere with normal maternal-infant bonding and adversely affect acute and longterm child development. Postpartum depression may lead mothers to be inconsistent with childcare.[26] These childcare inconsistencies may include feeding routines, sleep routines, and health maintenance.[26]

In rare cases, or about 1 to 2 per 1,000, the postpartum depression appears as postpartum psychosis.[11] In these, or among women with a history of previous psychiatric hospital admissions,[27] infanticide may occur. In the United States, postpartum depression is one of the leading causes of annual reported infanticide incidence rate of about 8 per 100,000 births.[2]

According to research published in the American Journal of Obstetrics and Gynecology, children can suffer the effects of postpartum depression. If a mother experiences postpartum depression that goes untreated, it can have adverse effects on her children. When a child is in infancy, these problems can include unusual amounts of crying (colic) and not having normal sleeping patterns. These problems can have a cyclical effect, meaning that they can further agitate the mother's postpartum depression and can even lead to the mother further developing postpartum depression. These cyclical effects can affect the way the mother maintains her relationship with her child. These can include the stopping of breastfeeding, as well as negative emotions such as withdrawal, disengagement, and even hostility. If a mother develops a hostile relationship, it can lead to extreme outcomes such as infanticide.

As the child grows older, postpartum depression can lead to the child experiencing irregularities in cognitive processes, behaviors, and emotions. In addition to these abnormalities, children who grew up around postpartum depression also are susceptible to developing violent tendencies.[2]

Postpartum Depression in FathersEdit

Paternal postpartum depression has not been studied as intently as its maternal counterpart. In men, postpartum depression is typically defined as "an episode of major depressive disorder (MDD) occurring soon after the birth of a child".[28] The cause may be distinct in males.[29] Symptoms of postpartum depression in men are extreme sadness, fatigue, anxiety, irritability, and suicidal thoughts. Postpartum depression in men is most likely to occur 3–6 months after delivery, and is correlated with maternal depression, meaning that if the mother is experiencing postpartum depression, then the father is at a higher risk of developing the illness as well.[30] Postpartum depression in men leads to an increase risk of suicide, while also limiting healthy infant-father attachment. Men who experience PPD can exhibit poor parenting behaviors, distress, and reduce infant interaction.[31] Reduced paternal interaction can later lead to cognitive and behavioral problems in children.[32]

CausesEdit

The cause of PPD is unknown. Hormonal and physical changes, personal and family history of depression, and the stress of caring for a new baby all may contribute to the development of postpartum depression.[33][34]

Evidence suggests that hormonal changes may play a role.[35] Understanding the neuroendocrinology characteristic of PPD has proven to be particularly challenging given the erratic changes to the brain and biological systems during pregnancy and postpartum. A review of exploratory studies in PPD have observed that women with PPD, have more dramatic changes in HPA axis activity, however directionality of specific hormone increases or decreases remain mixed.[36] Hormones which have been studied include estrogen, progesterone, thyroid hormone, testosterone, corticotropin releasing hormone, endorphins, and cortisol.[6] Estrogen and progesterone levels drop back to pre-pregnancy levels within 24 hours of giving birth, and that sudden change may cause it.[37] Aberrant steroid hormone–dependent regulation of neuronal calcium influx via extracellular matrix proteins and membrane receptors involved in responding to the cell’s microenvironment might be important in conferring biological risk.[38] The use of synthetic oxytocin, a birth-inducing drug, has been linked to increased rates of postpartum depression and anxiety.[39]

Fathers, who are not undergoing profound hormonal changes, can also have postpartum depression.[29] The cause may be distinct in males.

Profound lifestyle changes that are brought about by caring for the infant are also frequently hypothesized to cause PPD. However, little evidence supports this hypothesis. Mothers who have had several previous children without suffering PPD can nonetheless suffer it with their latest child.[40] Despite the biological and psychosocial changes that may accompany pregnancy and the postpartum period, most women are not diagnosed with PPD.[41][42] Many mothers are unable to get the rest they need to fully recover from giving birth. Sleep deprivation can lead to physical discomfort and exhaustion, which can contribute to the symptoms of postpartum depression.[43]

Risk factorsEdit

While the causes of PPD are not understood, a number of factors have been suggested to increase the risk. These risks can be broken down into two categories, biological and psychosocial:

Biological Risk FactorsEdit

The risk factors for postpartum depression can be broken down into two categories as listed above, biological and psychosocial.[46] Certain biological risk factors include the administration of oxytocin to induce labor. Chronic illnesses such as diabetes, or Addison's disease, as well as issues hypothalamic-pituitary-adrenal dysregulation (which controls hormonal responses),[44] inflammatory processes like asthma or celiac disease, and genetic vulnerabilities such as a family history of depression or PPD. Chronic illnesses caused by neuroendocrine irregularities including irritable bowl syndrome and fibromyalgia typically put individuals at risk for further health complications. However, it has been found that these diseases do not increase risk for postpartum depression, these factors are known to correlate with PPD.[44] This correlation does not mean these factors are causal. Cigarette smoking has been known to have additive effects.[45] Some studies have found a link between PPD and low levels of DHA (an omega-3 fatty acid) in the mother.[47] A correlation between postpartum thyroiditis and postpartum depression has been proposed but remains controversial. There may also be a link between postpartum depression and anti-thyroid antibodies.[48]

Psychosocial Risk FactorsEdit

The psychosocial risk factors for postpartum depression include severe life events, some forms of chronic strain, relationship quality, and support from partner and mother.[59] There is a need for more research in regard to the link between psychosocial risk factors and postpartum depression. Some psychosocial risk factors can be linked to the social determinants of health.[46] Women with fewer resources indicate a higher level of postpartum depression and stress than those women with more resources, such as financial.[60]

Rates of PPD have been shown to decrease as income increases. Women with fewer resources may be more likely to have an unintended or unwanted pregnancy, increasing risk of PPD. Women with fewer resources may also include single mothers of low income. Single mothers of low income may have more limited access to resources while transitioning into motherhood.

Studies have also shown a correlation between a mother's race and postpartum depression. African American mothers have been shown to have the highest risk of PPD at 25%, while Asian mothers had the lowest at 11.5%, after controlling for social factors such as age, income, education, marital status, and baby's health. The PPD rates for First Nations, Caucasian and Hispanic women fell in between.[60]

Migration away from a cultural community of support can be a factor in PPD. Traditional cultures around the world prioritize organized support during postpartum care to ensure the mother's mental and physical health, wellbeing, and recovery.[8]

One of the strongest predictors of paternal PPD is having a partner who has PPD, with fathers developing PPD 50% of the time when their female partner has PPD.[61]

Sexual orientation[62] has also been studied as a risk factor for PPD. In a 2007 study conducted by Ross and colleagues, lesbian and bisexual mothers were tested for PPD and then compared with a heterosexual sample group. It was found that lesbian and bisexual biological mothers had significantly higher Edinburgh Postnatal Depression Scale scores than did the heterosexual women in the sample.[44] These higher rates of PPD in lesbian/bisexual mothers may reflect less social support, particularly from their families of origin and additional stress due to homophobic discrimination in society.[63]

There is a call to integrate both a consideration of biological and psychosocial risk factors for PPD when treating and researching the illness.[46]

ViolenceEdit

A meta-analysis reviewing research on the association of violence and postpartum depression showed that violence against women increases the incidence of postpartum depression.[64] About one-third of women throughout the world will experience physical or sexual violence at some point in their lives.[65] Violence against women occurs in conflict, post-conflict, and non-conflict areas.[65] The research reviewed only looked at violence experienced by women from male perpetrators. Further, violence against women was defined as "any act of gender-based violence that results in, or is likely to result in, physical, sexual, or psychological harm or suffering to women".[64] Psychological and cultural factors associated with increased incidence of postpartum depression include family history of depression, stressful life events during early puberty or pregnancy, anxiety or depression during pregnancy, and low social support.[44][64] Violence against women is a chronic stressor, so depression may occur when someone is no longer able to respond to the violence.[64]

DiagnosisEdit

CriteriaEdit

Postpartum depression in the DSM-5 is known as "depressive disorder with peripartum onset". Peripartum onset is defined as starting anytime during pregnancy or within the four weeks following delivery. There is no longer a distinction made between depressive episodes that occur during pregnancy or those that occur after delivery.[66] Nevertheless, the majority of experts continue to diagnose postpartum depression as depression with onset anytime within the first year after delivery.[50]

The criteria required for the diagnosis of postpartum depression are the same as those required to make a diagnosis of non-childbirth related major depression or minor depression. The criteria include at least five of the following nine symptoms, within a two-week period:[66]

  • Feelings of sadness, emptiness, or hopelessness, nearly every day, for most of the day or the observation of a depressed mood made by others
  • Loss of interest or pleasure in activities
  • Weight loss or decreased appetite
  • Changes in sleep patterns
  • Feelings of restlessness
  • Loss of energy
  • Feelings of worthlessness or guilt
  • Loss of concentration or increased indecisiveness
  • Recurrent thoughts of death, with or without plans of suicide

Differential diagnosisEdit

Postpartum bluesEdit

Postpartum blues, commonly known as "baby blues," is a transient postpartum mood disorder characterized by milder depressive symptoms than postpartum depression. This type of depression can occur in up to 80% of all mothers following delivery.[67] Symptoms typically resolve within two weeks. Symptoms lasting longer than two weeks are a sign of a more serious type of depression.[68] Women who experience "baby blues" may have a higher risk of experiencing a more serious episode of depression later on.[69]

PsychosisEdit

Postpartum psychosis is not a formal diagnosis, but is widely used to describe a psychiatric emergency that appears to occur in about 1 in a 1000 pregnancies, in which symptoms of high mood and racing thoughts (mania), depression, severe confusion, loss of inhibition, paranoia, hallucinations and delusions begin suddenly in the first two weeks after delivery; the symptoms vary and can change quickly.[70] It is different from postpartum depression and from maternity blues.[71] It may be a form of bipolar disorder.[72] It is important not to confuse psychosis with other symptoms that may occur after delivery, such as delirium. Delirium typically includes a loss of awareness or inability to pay attention.[69]

About half of women who experience postpartum psychosis have no risk factors; but a prior history of mental illness, especially bipolar disorder, a history of prior episodes of postpartum psychosis, or a family history put some at a higher risk.[70]

Postpartum psychosis often requires hospitalization, where treatment is antipsychotic medications, mood stabilizers, and in cases of strong risk for suicide, electroconvulsive therapy.[70]

The most severe symptoms last from 2 to 12 weeks, and recovery takes 6 months to a year.[70] Women who have been hospitalized for a psychiatric condition immediately after delivery are at a much higher risk of suicide during the first year after delivery.[73]

Birth-Related/Postpartum Posttraumatic Stress Disorder

Although birth-related posttraumatic stress disorder is not recognized in the DSM-5, there is extensive research being conducted to bring awareness to the posttraumatic stress disorder symptoms one could experience following childbirth. Some research examines the differences and comorbidity when looking into birth-related posttraumatic stress disorder, or postpartum posttraumatic stress disorder, and postpartum depression.[74][75] In the recent research, similarities and differences in symptoms have been identified when it comes to postpartum posttraumatic stress disorder and postpartum depression.[74][75] Although both diagnoses have overlap in their diagnostic criteria, some of the criteria specific to postpartum depression include intense hopelessness and sadness, excessive worry or anxiety, intrusive thoughts of harm to oneself or harm to the baby, feelings of guilt or thoughts of worthlessness, and a change in appetite which could result in under-eating or overeating.[75] On the other hand, diagnostic criteria specific to postpartum posttraumatic stress disorder includes being easily startled, recurring nightmares and flashbacks, avoiding the baby or anything that reminds one of birth, aggression, irritability, and panic attacks.[74] Although these are the symptoms that often help differentiate between postpartum posttraumatic stress disorder and postpartum depression, it is important to note that some of these symptoms can cross over to the other diagnosis (e.g., someone meeting the diagnostic criteria of postpartum depression may also present with panic attacks, or someone meeting the diagnostic criteria for postpartum posttraumatic stress disorder may experience depressive episodes, etc.). Another crucial element in diagnosing postpartum posttraumatic stress disorder following childbirth is when there is a real or perceived trauma before, during, or following childbirth, which is not always required when it comes to diagnosing someone with postpartum depression.[76] This real or perceived traumatic event that could happen before, during, or following labor and delivery could be toward the baby, mother, or both. These traumatic events could include, but are not limited to unplanned c-section, death, the baby going into the NICU, the use of the vacuum extractor, or forceps during delivery, lack of support and/or reassurance during the delivery (from friends, family, and/or the medical staff), or any other severe physical complication or injury related to childbirth such as preeclampsia, or an unexpected hysterectomy.[77][78][79]

Conclusions have been made related to the idea of childbirth stressors and the contribution those can play in an increased risk of developing comorbid birth-related posttraumatic stress disorder and postpartum depression rather than only a postpartum depression diagnosis.[80] Findings like the one mentioned above are crucial in accurate diagnosis to provide the mothers with the most appropriate and effective treatment options, and to advance the validity and reliability of preventative assessments and strategies. Other studies have been able to identify obstetric and perinatal risk factors associated specifically with birth-related posttraumatic stress disorder including educational level, gestational age at delivery, number of prenatal care visits, pregnancy intervals, mode of delivery, any complications with pregnancy, and labor duration.[81][76][82] Based on current meta-analytic research, it has been concluded that the prevalence of postpartum posttraumatic stress disorder was 3.1% in community settings and 15.7% in at-risk populations; however, those findings do state various limitations, including underreporting biases, across the examined studies which lead many researchers to believe the prevalence may be higher.[76]

As of right now, there are no widely recognized assessments that measure for postpartum posttraumatic stress disorder in clinical and medical settings. However, researchers and physicians will often use more reliable posttraumatic stress disorder questionnaires and assessments, which are unfortunately not always specific enough to the posttraumatic symptoms and experiences that are felt before, during, or after childbirth. One assessment for postpartum posttraumatic stress disorder, the City Birth Trauma Scale (CBTS), has been used in some research settings; however, it is not widely used in clinical and medical settings.[74][83] The CBTS is a 29-item self-report questionnaire developed to measure birth-related posttraumatic stress disorder, according to the DSM-5 criteria of: symptoms of re-experiencing the event, avoidance, negative cognitions and mood, and hyperarousal, as well as the duration of one’s symptoms and the amount of distress and impairment the symptoms have caused in the individual’s life.[74] The creators of the CTSB also added in two items from the DSM-IV that they felt were relevant to the population being assessed with this measure – that the mothers responded to the traumatic events during childbirth with intense fear, helplessness, or horror and that there were symptoms of emotional numbing.[74] Although the emotional numbing component was excluded in the DSM-5 criteria for posttraumatic stress disorder, research has shown that when studying mothers who have been exposed to trauma, emotional numbing is more predictive of parenting stress than other posttraumatic stress disorder symptoms.[74][84] Although this assessment shows strong reliability (Cronbach’s alpha = 0.92), and participants from the pilot study found the measure to be easy to understand, this assessment is still not used in clinical or medical settings as often as it is used in research settings.[74] The researchers that have utilized the CTSB have been able to identify various limitations with the pilot study, including the lack of diversity in the sample demographic characteristics (93% White postpartum women) as well as the self-report nature of the assessment which could lead to underreporting of symptoms.[74] Another assessment that has also been used in research more often than in clinical or medical settings is the Perinatal Posttraumatic Stress Disorder Questionnaire (PPQ), which has since been modified into the Perinatal Posttraumatic Stress Disorder Questionnaire-II (PPQ-II), with the modified version being a 14-item scale which does not address all the necessary diagnostic criteria.[74][85][86] Further research and development are needed to create a more accurate assessments and screening tools that can differentiate among posttraumatic stress disorders, postpartum/childbirth-related posttraumatic stress disorder, and postpartum depression so that the most adequate treatment interventions and options can be implemented as quickly as possible.

ScreeningEdit

In the US, the American College of Obstetricians and Gynecologists suggests healthcare providers consider depression screening for perinatal women.[87] Additionally, the American Academy of Pediatrics recommends pediatricians screen mothers for PPD at 1-month, 2-month and 4-month visits.[88] However, many providers do not consistently provide screening and appropriate follow-up.[87][89] For example, in Canada, Alberta is the only province with universal PPD screening. This screening is carried out by Public Health nurses with the baby's immunization schedule.

The Edinburgh Postnatal Depression Scale, a standardized self-reported questionnaire, may be used to identify women who have postpartum depression.[90] If the new mother scores 13 or more, she likely has PPD and further assessment should follow.[90]

Healthcare providers may take a blood sample to test if another disorder is contributing to depression during the screening.[91]

The Edinburgh Postnatal Depression Scale, is used within the first week of their newborn being admitted. If mothers receive a score less than 12 they are told to be reassessed because of the depression testing protocol. It is also advised that mother's in the NICU to get screened every four to six weeks as their infant remains in the neonatal intensive care unit.[92] Mothers who score between twelve and nineteen on the EPDS are offered two types of support.[93] The mothers are offered LV treatment provided by a nurse in the NICU and they can be referred to the mental health professional services. If a mother receives a three on item number ten of the EPDS they are immediately referred to the social work team as they may be suicidal.[92]

PreventionEdit

A 2013 Cochrane review found evidence that psychosocial or psychological intervention after childbirth helped reduce the risk of postnatal depression.[94][95] These interventions included home visits, telephone-based peer support, and interpersonal psychotherapy.[94] Support is an important aspect of prevention, as depressed mothers commonly state that their feelings of depression were brought on by "lack of support" and "feeling isolated."[96]

Across different cultures, traditional rituals for postpartum care may be preventative for PPD, but are more effective when the support is welcomed by the mother.[97]

In couples, emotional closeness and global support by the partner protect against both perinatal depression and anxiety. Further factors such as communication between the couple and relationship satisfaction have a protective effect against anxiety alone.[98]

In those who are at risk counselling is recommended.[99] In 2018, 24% of areas in the UK have no access to perinatal mental health specialist services.[100]

Preventative treatment with antidepressants may be considered for those who have had PPD previously. However, as of 2017, the evidence supporting such use is weak.[101][102]

TreatmentsEdit

Treatment for mild to moderate PPD includes psychological interventions or antidepressants. Women with moderate to severe PPD would likely experience a greater benefit with a combination of psychological and medical interventions.[103] Light aerobic exercise has been found to be useful for mild and moderate cases.[104][105]

TherapyEdit

Both individual social and psychological interventions appear equally effective in the treatment of PPD.[106] Social interventions include individual counseling and peer support, while psychological interventions include cognitive behavioral therapy (CBT) and interpersonal therapy (IPT).[107] Interpersonal therapy (IPT) has shown to be effective in focusing specifically on the mother and infant bond.[108] Support groups and group therapy options focused on psychoeducation around postpartum depression have been shown to enhance the understanding of postpartum symptoms and often assist in finding further treatment options.[109] Other forms of therapy, such as group therapy, home visits, counseling, and ensuring greater sleep for the mother may also have a benefit.[13][5] While specialists trained in providing counseling interventions often serve this population in need, results from a recent systematic review and meta-analysis found that nonspecialist providers, including lay counselors, nurses, midwives, and teachers without formal training in counseling interventions, often provide effective services related to perinatal depression and anxiety.[110]

Internet-based cognitive behavioral therapy (iCBT) has shown promising results with lower negative parenting behavior scores and lower rates of anxiety, stress, and depression. iCBT may be beneficial for mothers who have limitations in accessing in person CBT. However, the long term benefits have not been determined.[111]

MedicationEdit

A 2010 review found few studies of medications for treating PPD noting small sample sizes and generally weak evidence.[107] Some evidence suggests that mothers with PPD will respond similarly to people with major depressive disorder.[107] There is low-certainty evidence which suggests that selective serotonin reuptake inhibitors (SSRIs) are effective treatment for PPD.[112] The first-line anti-depressant medication of choice is sertraline, an SSRI, as very little of it passes into the breast milk and, as a result, to the child.[5] However, a recent study has found that adding sertraline to psychotherapy does not appear to confer any additional benefit.[113] Therefore, it is not completely clear which antidepressants, if any, are most effective for treatment of PPD, and for whom antidepressants would be a better option than non-pharmacotherapy.[112]

Some studies show that hormone therapy may be effective in women with PPD, supported by the idea that the drop in estrogen and progesterone levels post-delivery contribute to depressive symptoms.[107] However, there is some controversy with this form of treatment because estrogen should not be given to people who are at higher risk of blood clots, which include women up to 12 weeks after delivery.[114] Additionally, none of the existing studies included women who were breastfeeding.[107] However, there is some evidence that the use of estradiol patches might help with PPD symptoms.[9]

Oxytocin has been shown to be an effective anxiolytic and in some cases antidepressant treatment in men and women. Exogenous oxytocin has only been explored as a PPD treatment with rodents, but results are encouraging for potential application in humans.[36]

In 2019, the FDA approved brexanolone, a synthetic analog of the neurosteroid allopregnanolone, for use intravenously in postpartum depression. Allopregnanolone levels drop after giving birth, which may lead to women becoming depressed and anxious.[115] Some trials have demonstrated an effect on PPD within 48 hours from the start of infusion.[116] Other new allopregnanolone analogs under evaluation for use in the treatment of PPD include SAGE-2017 and ganaxolone.[9]

Brexanolone has risks that can occur during administration, including excessive sedation and sudden loss of consciousness, and therefore has been approved under the Risk Evaluation and Mitigation Strategy (REMS) program.[117] The mother is to enrolled prior to receiving the medication. It is only available to those at certified health care facilities with a health care provider who can continually monitor the patient. The infusion itself is a 60-hour, or 2.5 day, process. People's oxygen levels are to be monitored with a pulse oximeter. Side effects of the medication include dry mouth, sleepiness, somnolence, flushing and loss of consciousness. It is also important to monitor for early signs of suicidal thoughts or behaviors.[117]

BreastfeedingEdit

Caution should be exercised when administering antidepressant medications during breastfeeding.[43] Most antidepressants are excreted in breast milk in low quantities which can have adverse effect on babies.[118] Regarding allopregnanolone, very limited data did not indicate a risk for the infant.[119]

OtherEdit

Electroconvulsive therapy (ECT) has shown efficacy in women with severe PPD that have either failed multiple trials of medication-based treatment or cannot tolerate the available antidepressants.[103] Tentative evidence supports the use of repetitive transcranial magnetic stimulation (rTMS).[120]

As of 2013 it is unclear if acupuncture, massage, bright lights, or taking omega-3 fatty acids are useful.[121]

EpidemiologyEdit

North AmericaEdit

United States

Within the United States, the prevalence of postpartum depression was lower than the global approximation at 11.5% but varied between states from as low as 8% to as high as 20.1%.[122]  The highest prevalence in the US is found among women who are American Indian/Alaska Natives or Asian/Pacific Islanders, possess less than 12 years of education, are unmarried, smoke during pregnancy, experience over two stressful life events, or who’s full term infant is low-birthweight or was admitted to a Newborn Intensive Care Unit. While US prevalence decreased from 2004 to 2012, it did not decrease among American Indian/Alaska Native women or those with full term, low-birthweight infants.[122]

Even with the variety of studies, it is difficult to find the exact rate as approximately 60% of US women are not diagnosed and of those diagnosed approximately 50% are not treated for PPD.[122] Cesarean section rates did not affect the rates of PPD. While there is discussion of postpartum depression in fathers, there is no formal diagnosis for postpartum depression in fathers.[123]

CanadaEdit

Since Canada has one of the largest refugee resettlement in the world with an equal percentage of women to men. This means that Canada has a disproportionate percentage of women that develop post-partum depression since there is an increased risk among the refugee population.[124] In a blind study, where women had to reach out and participate, around 27% of the sample population had symptoms consistent with post-partum depression without even knowing.[125] Also found that on average 8.46 women had minor and major PPDS was found to be 8.46 and 8.69% respectively. The main factors that were found to contribute in this study were the stress during pregnancy, the availability of support after, and a prior diagnosis of depression were all found to be factors.[126] Canada has the specific population demographics that also involve a large amount of immigrant and indigenous women which creates a specific cultural demographic localized to Canada. In this study researchers found that these two populations were at significantly higher risk compared to “Canadian born non-indigenous mothers”.[126] This study found that risk factors such as low education, low income cut off, taking antidepressants, and low social support are all factors that contribute to the higher percentage of these population in developing PPDS.[126] Specifically, indigenous mothers had the most risk factors then immigrant mothers with non-indigenous Canadian women being closer to the overall population.[127]

South AmericaEdit

A main issue surrounding PPD is the lack of study and the lack of reported prevalence that is based on studies developed in Western economically developed countries.[128] In countries such as Brazil, Guyana, Costa Rica, Italy, Chile, and South Africa there is actually a prevalence of report, around 60%. In an itemized research analysis put a mean prevalence at 10-15% percent but explicitly stated that cultural factors such as perception of mental health and stigma could possibly be preventing accurate reporting.[128] The analysis for south America shows that PPD occurs at a high rate looking comparatively at brazil (42%) Chile (4.6-48%) Guyana and Colombia (57%) and Venezuela (22%).[129] In most of these countries PPD is not considered a serious condition for women and therefore there is an absence of support programs for prevention and treatment in health systems.[129] Specifically, in Brazil PPD is identified through the family environment whereas in Chile PPD manifests itself through suicidal ideation and emotional instability.[129] In both cases most women feel regret and refuse to take care of the child showing that this illness is serious for both the mother and child.[129]

AsiaEdit

From a selected group of studies found from a literature search, researchers discovered many demographic factors of Asian populations that showed significant association with PPD. Some of these include age of mother at the time of childbirth as well as older age at marriage.[130] Being a migrant and giving birth to a child overseas has also been identified as a risk factor for PPD.[130] Specifically for Japanese women who were born and raised in Japan but who gave birth to their child in Hawaii, USA, about 50% of them experienced emotional dysfunction during their pregnancy.[130] In fact, all women who gave birth for the first time who were included in the study experienced PPD.[130] In immigrant Asian Indian women, the researchers found a minor depressive symptomatology rate of 28% and an additional major depressive symptomatology rate of 24% likely due to different health care attitudes in different cultures and distance form family leading to homesickness.[130]

In the context of Asian countries, premarital pregnancy is an important risk factor for PPD. This is because it is considered highly unacceptable in most Asian culture as there is a highly conservative attitude toward sex among Asian people than people in the west.[130] In addition, conflicts between mother and daughter-in-law are notoriously common in Asian societies as traditionally for them, marriage means the daughter-in-law joining and adjusting to the groom’s family completely. These conflicts may be responsible for emergence of PPD.[130] Regarding gender of the child, many studies have suggested dissatisfaction in infant’s gender (birth of a baby girl) is a risk factor for PPD. This is because in some Asian cultures, married couples are expected by the family to have at least one son to maintain the continuity of the bloodline which might lead a woman to experience PPD if she cannot give birth to a baby boy.[130]

EuropeEdit

There is a general assumption that Western cultures are homogenous and that there are no significant differences in psychiatric disorders across Europe and the USA. However, in reality factors associated with maternal depression, including work and environmental demands, access to universal maternity leave, health care, and financial security, are regulated and influenced by local policies that differ across countries.[131] For example, European social policies differ from country-to-country contrary to the USA, all countries provide some form of paid universal maternity leave and free health care.[131] Studies also found differences in symptomatic manifestations of PPD between European and American women.[132] Women from Europe reported higher scores of anhedonia, self-blaming, and anxiety, while women from the USA disclosed more severe insomnia, depressive feelings, and thoughts of self-harming.[131] Additionally, there are differences in prescribing patterns and attitudes towards certain medications between the USA and Europe which are indicative of how different countries approach treatment, and their different stigmas.[131]

AfricaEdit

Africa, like all other parts of the world struggles with a burden of postpartum depression. Current studies estimate the prevalence to be 15-25% but this is likely higher due to a lack of data and recorded cases. The magnitude of postpartum depression in South Africa is between 31.7% and 39.6%, in Morocco between 6.9% and 14%, in Nigeria between 10.7% and 22.9%, in Uganda 43%, in Tanzania 12%, in Zimbabwe 33%, in Sudan 9.2%, in Kenya between 13% and 18.7% and, 19.9% for participants in Ethiopia according to studies carried out in these countries among postpartum mothers between the ages of 17-49.[133] This demonstrates the gravity of this problem in Africa, and the need for postpartum depression to be taken seriously as a public health concern in the continent. Additionally, each of these studies were conducted using Western developed assessment tools. Cultural factors can affect diagnosis and can be a barrier to assessing the burden of disease.[133] Some recommendations to combat postpartum depression in Africa include considering postpartum depression as a public health problem that is neglected among postpartum mothers. Investing in research to assess the actual prevalence of postpartum depression, and encourage early screening, diagnosis and treatment of postpartum depression as an essential aspect of maternal care throughout Africa.[133]

Issues in Reporting Prevalence

Most studies regarding PPD are done using self-report screenings which are less reliable than clinical interviews.  This use of self-report may have results that underreport symptoms and thus postpartum depression rates.[134][122]

HistoryEdit

Prior to the 19th centuryEdit

Western medical science's understanding and construction of postpartum depression has evolved over the centuries. Ideas surrounding women’s moods and states have been around for a long time,[135] typically recorded by men. In 460 B.C., Hippocrates wrote about puerperal fever, agitation, delirium, and mania experienced by women after child birth.[136] Hippocrates' ideas still linger in how postpartum depression is seen today.[137]

A woman who lived in the 14th century, Margery Kempe, was a Christian mystic.[138] She was a pilgrim known as "Madwoman" after having a tough labor and delivery.[138] There was a long physical recovery period during which she started descending into "madness" and became suicidal.[138] Based on her descriptions of visions of demons and conversations she wrote about that she had with religious figures like God and the Virgin Mary, historians have identified what Margery Kempe was suffering from as "postnatal psychosis" and not postpartum depression.[139][140] This distinction became important to emphasize the difference between postpartum depression and postpartum psychosis. A 16th century physician, Castello Branco, documented a case of postpartum depression without the formal title as a relatively healthy woman who suffered from melancholy after childbirth, remained insane for a month, and recovered with treatment.[137] Although this treatment was not described, experimental treatments began to be implemented for postpartum depression for the centuries that followed.[137] Connections between female reproductive function and mental illness would continue to center around reproductive organs from this time all the way through to modern age, with a slowly evolving discussion around "female madness".[135]

19th century and afterEdit

With the 19th century came a new attitude about the relationship between female mental illness and pregnancy, childbirth, or menstruation.[141] The famous short story, "The Yellow Wallpaper", was published by Charlotte Perkins Gilman in this period. In the story, an unnamed woman journals her life when she is treated by her physician husband, John, for hysterical and depressive tendencies after the birth of their baby.[142] Gilman wrote the story to protest societal oppression of women as the result of her own experience as a patient.[143]

Also during the 19th century, gynecologists embraced the idea that female reproductive organs, and the natural processes they were involved in, were at fault for "female insanity."[144] Approximately 10% of asylum admissions during this time period are connected to “puerperal insanity,” the named intersection between pregnancy or childbirth and female mental illness.[145] It wasn't until the onset of the twentieth century that the attitude of the scientific community shifted once again: the consensus amongst gynecologists and other medical experts was to turn away from the idea of diseased reproductive organs and instead towards more "scientific theories" that encompassed a broadening medical perspective on mental illness.[144]

Society and cultureEdit

Legal recognitionEdit

Recently, postpartum depression has become more widely recognized in society. In the US, the Patient Protection and Affordable Care Act included a section focusing on research into postpartum conditions including postpartum depression.[146] Some argue that more resources in the form of policies, programs, and health objectives need to be directed to the care of those with PPD.[147]

Role of stigmaEdit

When stigma occurs, a person is labelled by their illness and viewed as part of a stereotyped group. There are three main elements of stigmas, 1) problems of knowledge (ignorance or misinformation), 2) problems of attitudes (prejudice), 3) problems of behavior (discrimination).[148] Specifically regarding PPD, it is often left untreated as women frequently report feeling ashamed about seeking help and are concerned about being labeled as a “bad mother” if they acknowledge that they are experiencing depression.[148] Although there has been previous research interest in depression-related stigma, few studies have addressed PPD stigma. One study studied PPD stigma through examining how an education intervention would impact it. They hypothesized that an education intervention would significantly influence PPD stigma scores.[148] Although they found some consistencies with previous mental health stigma studies, for example, that males had higher levels of personal PPD stigma than females, most of the PPD results were inconsistent with other mental health studies.[148] For example, they hypothesized that education intervention would lower PPD stigma scores, but in reality there was no significant impact and also familiarity with PPD was not associated with one's stigma towards people with PPD.[148] This study was a strong starting point for further PPD research, but clearly indicates more needs to be done in order to learn what the most effective anti-stigma strategies are specifically for PPD.[148]

Postpartum depression is still linked to significant stigma. This can also be difficult when trying to determine the true prevalence of postpartum depression. Participants in studies about PPD carry their beliefs, perceptions, cultural context and stigma of mental health in their cultures with them which can affect data.[128] The stigma of mental health - with or without support from family members and health professionals - often deters women from seeking help for their PPD. When medical help is achieved, some women find the diagnosis helpful and encourage a higher profile for PPD amongst the health professional community.[128]

Cultural beliefsEdit

Postpartum depression can be influenced by sociocultural factors.[128] There are many examples of particular cultures and societies that hold specific beliefs about PPD. Malay culture holds a belief in Hantu Meroyan; a spirit that resides in the placenta and amniotic fluid.[149]

When this spirit is unsatisfied and venting resentment, it causes the mother to experience frequent crying, loss of appetite, and trouble sleeping, known collectively as "sakit meroyan". The mother can be cured with the help of a shaman, who performs a séance to force the spirits to leave.[150]

Some cultures believe that the symptoms of postpartum depression or similar illnesses can be avoided through protective rituals in the period after birth. These may include offering structures of organized support, hygiene care, diet, rest, infant care, and breastfeeding instruction.[8] The rituals appear to be most effective when the support is welcomed by the mother.[97]

Some Chinese women participate in a ritual that is known as "doing the month" (confinement) in which they spend the first 30 days after giving birth resting in bed, while the mother or mother-in-law takes care of domestic duties and childcare. In addition, the new mother is not allowed to bathe or shower, wash her hair, clean her teeth, leave the house, or be blown by the wind.[151]

MediaEdit

Certain cases of postpartum mental health concerns received attention in the media and brought about dialogue on ways to address and understand more on postpartum mental health. Andrea Yates, a former nurse, became pregnant for the first time in 1993.[152] After giving birth to five children in the coming years, she suffered severe depression and had many depressive episodes. This led to her believing that her children needed to be saved, and that by killing them, she could rescue their eternal souls. She drowned her children one by one over the course of an hour, by holding their heads under water in their family bathtub. When called into trial, she felt that she had saved her children rather than harming them and that this action would contribute to defeating Satan.[153]

This was one of the first public and notable cases of postpartum psychosis,[152] which helped create dialogue on women's mental health after childbirth. The court found that Yates was experiencing mental illness concerns, and the trial started the conversation of mental illness in cases of murder and whether or not it would lessen the sentence or not. It also started a dialogue on women going against “maternal instinct” after childbirth and what maternal instinct was truly defined by.[153]

Yates' case brought wide media attention to the problem of filicide,[154] or the murder of children by their parents. Throughout history, both men and women have perpetrated this act, but study of maternal filicide is more extensive.

See alsoEdit

ReferencesEdit

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