New York State Route 22 (NY 22) is a north–south state highway in eastern New York in the United States. It runs parallel to the state's eastern edge from the outskirts of New York City to a short distance south of the Canada–US border. At 341 miles (549 km), it is the state's longest north–south route and the third longest overall, after NY 5 and NY 17.[a] Many of the state's major east–west roads intersect with Route 22 just before crossing the state line into the neighboring New England states.
The southernmost section of the road was known as the White Plains Post Road in the eighteenth and nineteenth centuries, a major highway connecting New York City to White Plains, the Westchester county seat. Route 22 in its modern form was established in 1930 as one of the principal routes from New York City to Canada.