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Piers David Nash (born 8 August 1969) is an entrepreneur, an evangelist for genomic data-informed Precision Medicine, data strategist, cancer biologist, writer and technology futurist. He is the son of academic Roger Nash.

Piers David Nash
20140718 ARD-Nash 5684.jpg
Nash in 2014
Born (1969-08-08) 8 August 1969 (age 50)
Exeter, England
NationalityUK, Canada, US
Alma materUniversity of Alberta
University of Guelph
Booth School of Business
Known forCellular signal transduction
Scientific career
FieldsBiochemistry, cell biology
InstitutionsUniversity of Chicago
Doctoral advisorGrant McFadden
InfluencesAnthony Pawson

Early life and educationEdit

Born in Exeter, England, and grew up in Sudbury, Ontario, Canada. In high school he competed in the Canada-Wide Science Fair in five successive years (1983–87), winning awards on each occasion and becoming one of the most highly awarded science fair participants in the history of the fair. In recognition of this he was selected to represent Canada as one of two youth delegates to the 1985 Nobel Prize lectures and ceremony in Stockholm, Sweden as part of the Stockholm International Youth Science Seminar and was awarded the International Youth Year Ontario Gold Medal. He received a BSc with honours in biochemistry from the University of Guelph, and the Chemical Institute of Canada prize for the top of class. He received a PhD in 1999 from the University of Alberta working in the laboratory of Dr. Grant McFadden investigating poxviral immunomodulatory proteins. His doctoral thesis focused on the enzymology and biological properties of the Myxoma virus encoded serine proteinase inhibitor (serpin), SERP-1. He completed postdoctoral research with Anthony Pawson at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and the University of Toronto from June 1999 to December 2003. In 2014, Nash received an MBA with a concentration in finance awarded with high honors from the University of Chicago Booth School of Business.

CareerEdit

Nash is the founder and CEO of Sympatic Inc [1]. Nash is Founder & General Manager of Nash Strategy & Innovation [2]. He advises Fortune 500 technology companies and startups in the genomics, healthcare, data science and data storage fields. He serves on the Advisory Boards of technology and innovation companies. Nash was Managing Director at Health2047, the innovation enterprise of the American Medical Association from 2017-2018. He was founding Strategy Manager, Director of business & research development for the University of Chicago's Center for Data Intensive Science which developed the National Cancer Institute Genomic Data Commons. He was a professor in the Ben May Department for Cancer Research and a Scientist of the Comprehensive Cancer Center at the University of Chicago from 2004–2012 and a fellow of the Institute for Genomics and Systems Biology[3] from 2006–2012. As a scientist, he investigates protein–protein interactions involved in signal transduction, and the molecular mechanisms by which cells respond to external cues. His work at the University of Chicago focused on understanding the SH2 domain at a systems level and investigating the role of ubiquitination in controlling endocytosis and modulating signal transduction. Earlier work focused on the emergent properties of complex systems such as ultrasensitivity (all-or-none switches) at critical junctures in the cell cycle.

ResearchGate reports 54 peer-reviewed published works in a wide range of fields, including signal transduction, cell biology, molecular evolution, cell cycle, cognition and memory, meteorology, and pedagogy.[4] Scopus notes an h-index of 30 and 4488 citations[5] of 51 publications tracked in that database since 1996.

PublicationsEdit

Research PapersEdit

  • Nash, P. (1984). "Differential Effects of Wind Speed on Low Temperature Evaporation". Chinook. 6: 92–3.
  • Nash, C. H.; Nash, P. (1986). "Correlates of Colour Memory: A Neglected Field of Research". Future Health. 8: 15–6.
  • Nash, Piers D.; Davison, Laura (Winter 1989). "What Gifted Secondary School Students Tell about Their School Programs". Canadian Journal of Education. 14 (1): 109–18. doi:10.2307/1495206. JSTOR 1495206.
  • Maksymowych, WP; Nation, N; Nash, P; Macen, J; Lucas, A; McFadden, G; Russell, AS (1996). "Amelioration of antigen induced arthritis in rabbits treated with a secreted viral serine proteinase inhibitor". The Journal of Rheumatology. 23 (5): 878–82. PMID 8724302.
  • Lucas, A.; Liu, L.-y.; Macen, J.; Nash, P.; Dai, E.; Stewart, M.; Graham, K.; Etches, W.; et al. (1996). "Virus-Encoded Serine Proteinase Inhibitor SERP-1 Inhibits Atherosclerotic Plaque Development After Balloon Angioplasty". Circulation. 94 (11): 2890–900. doi:10.1161/01.CIR.94.11.2890. PMID 8941118.
  • Nash, P.; Whitty, A; Handwerker, J; Macen, J; McFadden, G (1998). "Inhibitory Specificity of the Anti-inflammatory Myxoma Virus Serpin, SERP-1". Journal of Biological Chemistry. 273 (33): 20982–91. doi:10.1074/jbc.273.33.20982. PMID 9694848.
  • Christov, Alexander; Dai, Erbin; Liu, Liying; Miller, Leslie W.; Nash, Piers; Lalani, Alshad; McFadden, Grant; Nation, Patric N.; et al. (1999). "Detection of transplant vasculopathy in a rat aortic allograft model by fluorescence spectroscopic optical analysis". Lasers in Surgery and Medicine. 24 (5): 346–59. doi:10.1002/(SICI)1096-9101(1999)24:5<346::AID-LSM5>3.0.CO;2-K. PMID 10406475.
  • Miller, L. W.; Dai, E.; Nash, P.; Liu, L.; Icton, C.; Klironomos, D.; Fan, L.; Nation, P. N.; et al. (2000). "Inhibition of Transplant Vasculopathy in a Rat Aortic Allograft Model After Infusion of Anti-Inflammatory Viral Serpin". Circulation. 101 (13): 1598–605. doi:10.1161/01.CIR.101.13.1598. PMID 10747355.
  • Lucas, A; Dai, E; Liu, L; Guan, H; Nash, P; McFadden, G; Miller, L (2000). "Transplant vasculopathy: Viral anti-inflammatory serpin regulation of atherogenesis". The Journal of Heart and Lung Transplantation. 19 (11): 1029–38. doi:10.1016/S1053-2498(00)00190-X. PMID 11077219.
  • Nash, P; Barry, M; Seet, BT; Veugelers, K; Hota, S; Heger, J; Hodgkinson, C; Graham, K; et al. (2000). "Post-translational modification of the myxoma-virus anti-inflammatory serpin SERP-1 by a virally encoded sialyltransferase". The Biochemical Journal. 347 (Pt 2): 375–82. doi:10.1042/0264-6021:3470375. PMC 1220969. PMID 10749666.
  • Christov, Alexander; Dai, Erbin; Drangova, Maria; Liu, Liying; Abela, George S.; Nash, Piers; McFadden, Grant; Lucas, Alexandra (2007). "Optical Detection of Triggered Atherosclerotic Plaque Disruption by Fluorescence Emission Analysis". Photochemistry and Photobiology. 72 (2): 242–52. doi:10.1562/0031-8655(2000)0720242ODOTAP2.0.CO2. PMID 10946579.
  • Nash, Piers; McFadden, Grant; Whitty, Adrian (2000). "Application of linear free energy relationships to the serpin–proteinase inhibition mechanism". FEBS Letters. 475 (1): 1–6. doi:10.1016/S0014-5793(00)01620-3. PMID 10854846.
  • Nash, Piers; Tang, Xiaojing; Orlicky, Stephen; Chen, Qinghua; Gertler, Frank B.; Mendenhall, Michael D.; Sicheri, Frank; Pawson, Tony; Tyers, Mike (2001). "Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication". Nature. 414 (6863): 514–21. Bibcode:2001Natur.414..514N. doi:10.1038/35107009. PMID 11734846.
This article was the focus of the following reviews and comments:
Ferrell, James E. (2001). "Cell cycleSix steps to destruction". Nature. 414 (6863): 498–9. Bibcode:2001Natur.414..498F. doi:10.1038/35107180. PMID 11734834.
Deshaies, Raymond J.; Ferrell Jr., James E. (2001). "Multisite Phosphorylation and the Countdown to S Phase". Cell. 107 (7): 819–22. doi:10.1016/S0092-8674(01)00620-1. PMID 11779457.
Harper, J.Wade (2002). "A phosphorylation-driven ubiquitination switch for cell-cycle control". Trends in Cell Biology. 12 (3): 104–7. doi:10.1016/S0962-8924(01)02238-3. PMID 11859016.
Tromans, Amanda (2001). "Switching on S phase". Nature Reviews Molecular Cell Biology. 2 (12): 873. doi:10.1038/35103051. PMID 11733763.
Adler, E. M.; Gough, N. R.; Ray, L. B. (2005). "2004: Signaling Breakthroughs of the Year". Science Signaling. 2005 (265): eg1. doi:10.1126/stke.2652005eg1.

Book ChaptersEdit

Review ArticlesEdit

This was the focus of the following review:
Gough, N. R.; Adler, E. M.; Ray, L. B. (2003). "Focus Issue: Cellular Regulation Through Protein Interaction Domains". Science Signaling. 2003 (179): eg6. doi:10.1126/scisignal.1792003eg6.

Honors and awardsEdit

NotesEdit

  1. ^ https://sympatichealth.com
  2. ^ https://piersnash.com
  3. ^ http://www.igsb.org Institute for Genomics and Systems Biology
  4. ^ ResearchGate Profile of Piers Nash 30 October 2014 (see External Links)
  5. ^ Scopus profile of Piers D. Nash 17 May 2018 (see External Links)

External linksEdit