Phosgene is the chemical compound with the formula COCl2. A colorless gas, in low concentrations its odor resembles freshly cut hay or grass. Phosgene is a valued industrial reagent and building block in synthesis of pharmaceuticals and other organic compounds. It gained infamy as a chemical weapon during World War I where it was responsible for about 85% of the 100,000 deaths caused by chemical weapons. In addition to its industrial production, small amounts occur from the breakdown and the combustion of organochlorine compounds, such as those used in refrigeration systems. The chemical was named by combining the Greek words "phos" (meaning light) and "genesis" (birth); it does not mean it contains any phosphorus (cf. phosphine).
|Preferred IUPAC name
Carbon dichloride oxide
3D model (JSmol)
|Molar mass||98.92 g/mol|
|Odor||Suffocating, like musty hay|
|Density||4.248 g/L (15 °C, gas)
1.432 g/cm3 (0 °C, liquid)
|Melting point||−118 °C (−180 °F; 155 K)|
|Boiling point||8.3 °C (46.9 °F; 281.4 K)|
|Solubility||Soluble in benzene, toluene, acetic acid
Decomposes in alcohol and acid
|Vapor pressure||1.6 atm (20°C)|
|Safety data sheet||ICSC 0007|
|R-phrases (outdated)||R26 R34|
|S-phrases (outdated)||(S1/2) S9 S26 S36/37/39 S45|
|Lethal dose or concentration (LD, LC):|
LC50 (median concentration)
|500 ppm (human, 1 min)
340 ppm (rat, 30 min)
438 ppm (mouse, 30 min)
243 ppm (rabbit, 30 min)
316 ppm (guinea pig, 30 min)
1022 ppm (dog, 20 min)
145 ppm (monkey, 1 min)
LCLo (lowest published)
|3 ppm (human, 2.83 h)
30 ppm (human, 17 min)
50 ppm (mammal, 5 min)
88 ppm (human, 30 min)
46 ppm (cat, 15 min)
50 ppm (human, 5 min)
2.7 ppm (mammal, 30 min)
|US health exposure limits (NIOSH):|
|TWA 0.1 ppm (0.4 mg/m3)|
|TWA 0.1 ppm (0.4 mg/m3) C 0.2 ppm (0.8 mg/m3) [15-minute]|
IDLH (Immediate danger)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Structure and basic propertiesEdit
Phosgene is a planar molecule as predicted by VSEPR theory. The C=O distance is 1.18 Å, the C−Cl distance is 1.74 Å and the Cl−C−Cl angle is 111.8°. It is one of the simplest acid chlorides, being formally derived from carbonic acid.
- CO + Cl2 → COCl2 (ΔHrxn = −107.6 kJ/mol)
The reaction is exothermic, therefore the reactor must be cooled. Typically, the reaction is conducted between 50 and 150 °C. Above 200 °C, phosgene reverts to carbon monoxide and chlorine, Keq(300 K) = 0.05. World production of this compound was estimated to be 2.74 million tonnes in 1989.
Because of safety issues, phosgene is often produced and consumed within the same plant, and extraordinary measures are made to contain it. It is listed on schedule 3 of the Chemical Weapons Convention: All production sites manufacturing more than 30 tonnes per year must be declared to the OPCW. Although less dangerous than many other chemical weapons, such as sarin, phosgene is still regarded as a viable chemical warfare agent because it is so easy to manufacture when compared to the production requirements of more technically advanced chemical weapons such as the first-generation nerve agent tabun.
Upon ultraviolet (UV) radiation in the presence of oxygen, chloroform slowly converts into phosgene by a radical reaction. To suppress this photodegradation, chloroform is often stored in brown-tinted glass containers and with a small percentage of ethanol added. Chlorinated compounds used to remove oil from metals, such as automotive brake cleaners, are converted to phosgene by the UV rays of arc welding processes.
Phosgene may also be produced during testing for leaks of older-style refrigerant gases. Chloromethanes (R12, R22 and others) were formerly leak-tested in situ by employing a small gas torch (propane, butane or propylene gas) with a sniffer tube and a copper reaction plate in the flame nozzle of the torch. If any refrigerant gas was leaking from a pipe or joint, the gas would be sucked into the flame through the sniffer tube and would cause a colour change of the gas flame to a bright greenish blue. In the process, phosgene gas would be created due to the thermal reaction. No valid statistics are available, but anecdotal reports suggest that numerous refrigeration technicians suffered the effects of phosgene poisoning due to their ignorance of the toxicity of phosgene, produced during such leak testing. Electronic sensing of refrigerant gases phased out the use of flame testing for leaks in the 1980s. Similarly, phosgene poisoning is a possibility for people fighting fires that occur in the vicinity of refrigerant leaks from air-conditioning systems or refrigeration equipment, smoking in the vicinity of a freon refrigerant leak, or fighting fires using halon or halotron.
Phosgene can be released during building fires. In one instance, a deputy fire chief died ten days after inhaling fumes that wafted down outside a burning restaurant. After a two-day hospitalization he had appeared to recover, but ultimately suffered cardiac arrest at home following tracheobronchial inflammation, alveolar hemorrhage, and pulmonary edema. The phosgene was produced by decomposing Freon-22 after flames ducted up from a grease fire heated an air-conditioning unit on the roof and ruptured a hose.
Phosgene was synthesized by the Cornish chemist John Davy (1790–1868) in 1812 by exposing a mixture of carbon monoxide and chlorine to sunlight. He named it "phosgene" in reference of the use of light to promote the reaction; from Greek, phos (light) and gene (born). It gradually became important in the chemical industry as the 19th century progressed, particularly in dye manufacturing.
The great majority of phosgene is used in the production of isocyanates, the most important being toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). These two isocyanates are precursors to polyurethanes.
Synthesis of carbonatesEdit
Significant amounts are also used in the production of polycarbonates by its reaction with bisphenol A. Polycarbonates are an important class of engineering thermoplastic found, for example, in lenses in eyeglasses. Diols react with phosgene to give either linear or cyclic carbonates (R = H, alkyl, aryl):
- HOCR2−X−CR2OH + COCl2 → 1⁄n [OCR2−X−CR2OC(O)−]n + 2 HCl
Synthesis of isocyanatesEdit
In the research laboratory phosgene still finds limited use in organic synthesis. A variety of substitutes have been developed, notably trichloromethyl chloroformate ("diphosgene"), a liquid at room temperature, and bis(trichloromethyl) carbonate ("triphosgene"), a crystalline substance. Aside from the above reactions that are widely practiced industrially, phosgene is also used to produce acid chlorides and carbon dioxide from carboxylic acids:
- RCO2H + COCl2 → RC(O)Cl + HCl + CO2
Such acid chlorides react with amines and alcohols to give, respectively, amides and esters, which are commonly used intermediates. Thionyl chloride is more commonly and more safely employed for this application. A specific application for phosgene is the production of chloroformic esters:
- ROH + COCl2 → ROC(O)Cl + HCl
Phosgene is stored in metal cylinders. The outlet is always standard, a tapered thread that is known as CGA 160
- COCl2 + H2O → CO2 + 2 HCl
Analogously, with ammonia, one obtains urea:
- COCl2 + 4 NH3 → CO(NH2)2 + 2 NH4Cl
The collapse of international conventions against chemical weapons led to the widespread use of chlorine gas in World War I, but its lethal dose was 1000 parts per million, visible as a green cloud in the air, allowing troops to take readily available countermeasures. Phosgene, colorless with a more subtle "moldy hay" odor, was introduced by a group of French chemists led by Victor Grignard and first used by the French in 1915. It was also used in a mixture with an equal volume of chlorine, with the chlorine helping to spread the denser phosgene. Phosgene was more potent than chlorine, though some of the symptoms of exposure took 24 hours or more to manifest, meaning the victims were initially still capable of putting up a fight.
Phosgene was then only frequently used by the Imperial Japanese Army against the Chinese during the Second Sino-Japanese War. Gas weapons, such as phosgene, were produced by Unit 731 and authorized by specific orders given by Hirohito (Emperor Showa) himself, transmitted by the chief of staff of the army. For example, the Emperor authorized the use of toxic gas on 375 separate occasions during the Battle of Wuhan from August to October 1938.
Phosgene is an insidious poison as the odor may not be noticed and symptoms may be slow to appear.
The odor detection threshold for phosgene is 0.4 ppm, four times the threshold limit value. Its high toxicity arises from the action of the phosgene on the proteins in the pulmonary alveoli, the site of gas exchange: their damage disrupts the blood–air barrier, causing suffocation. It reacts with the amines of the proteins, causing crosslinking by formation of urea-like linkages, in accord with the reactions discussed above. Phosgene detection badges are worn by those at risk of exposure.
- Merck Index, 11th Edition, 7310.
- Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. 2014. p. 798. doi:10.1039/9781849733069-FP001. ISBN 978-0-85404-182-4.
- "NIOSH Pocket Guide to Chemical Hazards #0504". National Institute for Occupational Safety and Health (NIOSH).
- "PHOSGENE (cylinder)". Inchem (Chemical Safety Information from Intergovernmental Organizations). International Programme on Chemical Safety and the European Commission.
- "Phosgene". Immediately Dangerous to Life and Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
- CBRNE - Lung-Damaging Agents, Phosgene May 27, 2009
- Wolfgang Schneider; Werner Diller (2005), "Phosgene", Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH, doi:10.1002/14356007.a19_411
- Nakata, M.; Kohata, K.; Fukuyama, T.; Kuchitsu, K. (1980). "Molecular Structure of Phosgene as Studied by Gas Electron Diffraction and Microwave Spectroscopy. The rz Structure and Isotope Effect". Journal of Molecular Spectroscopy. 83: 105–117. doi:10.1016/0022-2852(80)90314-8.
- Annex on Implementation and Verification ("Verification Annex").
- "Common Cleaners Can Turn Into Poison Gas". American Iron Magazine. TAM Communications. Retrieved 14 October 2011.
- Fireground Medical Operations, Albert Einstein Medical Center. "'Just a routine fire'".
- John Davy (1812). "On a gaseous compound of carbonic oxide and chlorine". Philosophical Transactions of the Royal Society of London. 102: 144–151. doi:10.1098/rstl.1812.0008. JSTOR 107310. Phosgene was named on p. 151: " ... it will be necessary to designate it by some simple name. I venture to propose that of phosgene, or phosgene gas; from φως, light, γινομαι, to produce, which signifies formed by light; ... "
- R. L. Shriner, W. H. Horne, and R. F. B. Cox (1943). "p-Nitrophenyl Isocyanate". Organic Syntheses. ; Collective Volume, 2, p. 453
- Hamley, P. "Phosgene" Encyclopedia of Reagents for Organic Synthesis, 2001 John Wiley, New York. doi: 10.1002/047084289X.rp149
- Nye, Mary Jo (1999). Before big science: the pursuit of modern chemistry and physics, 1800–1940. Harvard University Press. p. 193. ISBN 0-674-06382-1.
- Staff (2004). "Choking Agent: CG". CBWInfo. Retrieved 2007-07-30.
- Kiester, Edwin; et al. (2007). An Incomplete History of World War I. 1. Murdoch Books. p. 74. ISBN 1-74045-970-9.
- Staff (22 February 2006). "Facts About Phosgene". CDC. Retrieved 2008-05-23.
- Base's phantom war reveals its secrets, Lithgow Mercury, 7/08/2008
- Chemical warfare left its legacy, Lithgow Mercury, 9/09/2008
- Chemical bombs sit metres from Lithgow families for 60 years, The Daily Telegraph, September 22, 2008
- Ryan, T.Anthony (1996). Phosgene and Related Carbonyl Halides. Elsevier. pp. 154–155. ISBN 0444824456.
- Yuki Tanaka, "Poison Gas, the Story Japan Would Like to Forget", Bulletin of the Atomic Scientists, October 1988, pp. 16–17
- Y. Yoshimi and S. Matsuno, Dokugasusen Kankei Shiryô II, Kaisetsu, Jugonen Sensô Gokuhi Shiryoshu, 1997, pp. 27–29
- Borak J.; Diller W. F. (2001). "Phosgene exposure: mechanisms of injury and treatment strategies". Journal of Occupational and Environmental Medicine. 43 (2): 110–9. doi:10.1097/00043764-200102000-00008. PMID 11227628.
- "Phosgene: Health and Safety Guide". International Programme on Chemical Safety. 1998.
- Davy's account of his discovery of phosgene
- International Chemical Safety Card 0007
- CDC - Phosgene - NIOSH Workplace Safety and Health Topic
- NIOSH Pocket Guide to Chemical Hazards
- U.S. CDC Emergency Preparedness & Response
- U.S. EPA Acute Exposure Guideline Levels
- Regime For Schedule 3 Chemicals And Facilities Related To Such Chemicals, OPCW website
- CBWInfo website
- Use of Phosgene in WWII and in modern-day warfare