The Greek name Paphnutius (Παφνούτιος) takes its origin in Egyptian pa-ph-nuti ("the [man] of God" or "that who belongs to God"; see the Coptic name "Papnoute"). The name entered Russian as Пафнутий (for example, the famous mathematician Pafnuty Chebyshev).
- Paphnutius of Tentyra (3rd century AD), follower of a saint
- Paphnutius of Thebes (4th century AD), aka "Paphnutius the Confessor", a bishop
- Paphnutius the Ascetic (4th century AD), aka "Paphnutius the Hermit"
- Paphnutius of Jerusalem; see April 19 (Eastern Orthodox liturgics)
- Paphnutius, recluse of the Kiev Caves Monastery
- Paphnutius of Borovsk; see List of Russian saints (until 15th century)
- Paphnutius the Bishop (10th century AD)
- Paphnutius (play), a medieval play about the ascetic