Lysosomal thioesterase PPT2 (PPT-2), also known as S-thioesterase G14, is an enzyme that in humans is encoded by the PPT2 gene.[5][6][7]

PPT2
PDB 1pja EBI.jpg
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPT2, C6orf8, G14, PPT-2, palmitoyl-protein thioesterase 2
External IDsOMIM: 603298 MGI: 1860075 HomoloGene: 10448 GeneCards: PPT2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138934
NM_001204103
NM_005155
NM_138717

NM_019441
NM_001302393
NM_001302394
NM_001302395
NM_001302396

RefSeq (protein)

NP_001191032
NP_005146
NP_619731

NP_001289322
NP_001289323
NP_001289324
NP_001289325
NP_062314

Location (UCSC)Chr 6: 32.15 – 32.16 MbChr 17: 34.62 – 34.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FunctionEdit

This gene encodes a member of the palmitoyl protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins.[5]

ReferencesEdit

  1. ^ a b c ENSG00000231618, ENSG00000168452, ENSG00000228116, ENSG00000236649, ENSG00000206256, ENSG00000206329, ENSG00000221988 GRCh38: Ensembl release 89: ENSG00000227600, ENSG00000231618, ENSG00000168452, ENSG00000228116, ENSG00000236649, ENSG00000206256, ENSG00000206329, ENSG00000221988 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015474 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: palmitoyl-protein thioesterase 2".
  6. ^ Soyombo AA, Hofmann SL (October 1997). "Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity". J. Biol. Chem. 272 (43): 27456–63. doi:10.1074/jbc.272.43.27456. PMID 9341199.
  7. ^ Soyombo AA, Yi W, Hofmann SL (March 1999). "Structure of the human palmitoyl-protein thioesterase-2 gene (PPT2) in the major histocompatibility complex on chromosome 6p21.3". Genomics. 56 (2): 208–16. doi:10.1006/geno.1998.5703. PMID 10051407.

Further readingEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.