PLA2G2D

Group IID secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G2D gene.

PLA2G2D
Identifiers
Aliases	PLA2G2D, PLA2IID, SPLASH, sPLA2-IID, sPLA2S, phospholipase A2 group IID
External IDs	OMIM: 605630 MGI: 1341796 HomoloGene: 7892 GeneCards: PLA2G2D
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.12 Start 20,111,939 bp End 20,119,566 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D3|4 70.57 cM Start 138,503,046 bp End 138,509,357 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node appendix bone marrow cells rectum spleen gallbladder thymus pharynx thymus superior surface of tongue Top expressed in spleen interventricular septum thymus sciatic nerve subcutaneous adipose tissue white adipose tissue lip upper arm mammary gland Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding phospholipase A2 activity heparin binding metal ion binding heparan sulfate proteoglycan binding hydrolase activity phospholipid binding calcium-dependent phospholipase A2 activity Cellular component extracellular region Biological process phosphatidic acid biosynthetic process phosphatidylserine acyl-chain remodeling phosphatidylethanolamine acyl-chain remodeling CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation lipid metabolism phosphatidylinositol acyl-chain remodeling lipid catabolic process negative regulation of T cell proliferation phosphatidylglycerol acyl-chain remodeling inflammatory response negative regulation of T cell activation phosphatidylcholine acyl-chain remodeling phospholipid metabolic process arachidonic acid secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26279 18782 Ensembl ENSG00000117215 ENSMUSG00000041202 UniProt Q9UNK4 Q9WVF6 RefSeq (mRNA) NM_012400 NM_001271814 NM_011109 NM_001347230 RefSeq (protein) NP_001258743 NP_036532 NP_001334159 NP_035239 Location (UCSC) Chr 1: 20.11 – 20.12 Mb Chr 4: 138.5 – 138.51 Mb PubMed search
Wikidata
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Further reading

• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
• Leslie CC (2004). "Regulation of arachidonic acid availability for eicosanoid production". Biochem. Cell Biol. 82 (1): 1–17. doi:10.1139/o03-080. PMID 15052324.
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Shakhov AN, Rubtsov AV, Lyakhov IG, et al. (2001). "SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency". Genes Immun. 1 (3): 191–9. doi:10.1038/sj.gene.6363659. PMID 11196711.
• Lindbom J, Ljungman AG, Lindahl M, Tagesson C (2003). "Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma". J. Interferon Cytokine Res. 22 (9): 947–55. doi:10.1089/10799900260286650. PMID 12396716.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Eckey R, Menschikowski M, Lattke P, Jaross W (2005). "Increased hepatic cholesterol accumulation in transgenic mice overexpressing human secretory phospholipase A2 group IIA". Inflammation. 28 (2): 59–65. doi:10.1023/B:IFLA.0000033021.44105.9c. PMID 15379211. S2CID 21189952.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Takabatake N, Sata M, Inoue S, et al. (2006). "A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease". Am. J. Respir. Crit. Care Med. 172 (9): 1097–104. doi:10.1164/rccm.200503-319OC. PMID 16002569.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Lindbom J, Ljungman AG, Tagesson C (2007). "Interferon gamma-induced gene expression of the novel secretory phospholipase A2 type IID in human monocyte-derived macrophages is inhibited by lipopolysaccharide". Inflammation. 29 (2–3): 108–117. doi:10.1007/s10753-006-9007-x. PMID 16897354. S2CID 22943118.