PDE1C

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C is an enzyme that in humans is encoded by the PDE1C gene.

PDE1C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LXS
Identifiers
Aliases	PDE1C, Hcam3, cam-PDE 1C, hCam-3, phosphodiesterase 1C, DFNA74
External IDs	OMIM: 602987 MGI: 108413 HomoloGene: 3682 GeneCards: PDE1C
Gene location (Human) Chr. Chromosome 7 (human) Band 7p14.3 Start 31,751,179 bp End 32,428,131 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 B3|6 27.65 cM Start 56,046,789 bp End 56,629,472 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell right ventricle corpus callosum left ventricle sural nerve inferior ganglion of vagus nerve external globus pallidus internal globus pallidus subthalamic nucleus left uterine tube Top expressed in spermatocyte spermatid retinal pigment epithelium supraoptic nucleus aortic valve ascending aorta ciliary body iris olfactory epithelium epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoric diester hydrolase activity calmodulin-dependent cyclic-nucleotide phosphodiesterase activity hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity metal ion binding calmodulin binding calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity Cellular component cytosol neuronal cell body Biological process signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5137 18575 Ensembl ENSG00000154678 ENSMUSG00000004347 UniProt Q14123 Q64338 RefSeq (mRNA) NM_001191056 NM_001191057 NM_001191058 NM_001191059 NM_005020 NM_001322055 NM_001322056 NM_001322057 NM_001322058 NM_001322059 NM_001025568 NM_001159952 NM_001159953 NM_001159955 NM_001159956 NM_001159957 NM_001159960 NM_011054 NM_001355475 RefSeq (protein) NP_001177985 NP_001177986 NP_001177987 NP_001177988 NP_001308984 NP_001308985 NP_001308986 NP_001308987 NP_001308988 NP_005011 NP_001020739 NP_001153424 NP_001153425 NP_001153427 NP_001153428 NP_001153429 NP_001153432 NP_035184 NP_001342404 Location (UCSC) Chr 7: 31.75 – 32.43 Mb Chr 6: 56.05 – 56.63 Mb PubMed search
Wikidata
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Further reading

• Vandeput F, Wolda SL, Krall J, et al. (2007). "Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes". J. Biol. Chem. 282 (45): 32749–57. doi:10.1074/jbc.M703173200. PMID 17726023.
• Dolci S, Belmonte A, Santone R, et al. (2006). "Subcellular localization and regulation of type-1C and type-5 phosphodiesterases". Biochem. Biophys. Res. Commun. 341 (3): 837–46. doi:10.1016/j.bbrc.2006.01.035. hdl:11573/979485. PMID 16455054.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rybalkin SD, Rybalkina I, Beavo JA, Bornfeldt KE (2002). "Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation". Circ. Res. 90 (2): 151–7. doi:10.1161/hh0202.104108. PMID 11834707.
• Yan C, Zhao AZ, Sonnenburg WK, Beavo JA (2001). "Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis". Biol. Reprod. 64 (6): 1746–54. doi:10.1095/biolreprod64.6.1746. PMID 11369604.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.