PDE1A

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.

PDE1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LXQ
Identifiers
Aliases	PDE1A, CAM-PDE-1A, HCAM-1, HCAM1, HSphosphodiesterase 1A, CAM-PDE 1A
External IDs	OMIM: 171890 MGI: 1201792 HomoloGene: 21043 GeneCards: PDE1A
Gene location (Human) Chr. Chromosome 2 (human) Band 2q32.1 Start 182,139,968 bp End 182,523,359 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C3 Start 79,664,797 bp End 79,959,802 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Brodmann area 23 middle temporal gyrus renal medulla entorhinal cortex parietal lobe postcentral gyrus superior frontal gyrus cerebellar cortex cerebellar hemisphere Top expressed in spermatid seminiferous tubule superior frontal gyrus subiculum primary motor cortex Region I of hippocampus proper nucleus accumbens spermatocyte endocardial cushion ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoric diester hydrolase activity calmodulin-dependent cyclic-nucleotide phosphodiesterase activity hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity metal ion binding calmodulin binding calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity cGMP binding 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity Cellular component cytosol cytoplasm nucleus neuronal cell body Biological process cGMP catabolic process cAMP catabolic process signal transduction regulation of smooth muscle cell apoptotic process regulation of smooth muscle cell proliferation G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5136 18573 Ensembl ENSG00000115252 ENSMUSG00000059173 UniProt P54750 Q9Y633 Q61481 RefSeq (mRNA) NM_001003683 NM_001258312 NM_001258313 NM_001258314 NM_005019 NM_001363871 NM_001395258 NM_001395259 NM_001395260 NM_001395261 NM_001395262 NM_001395263 NM_001395264 NM_001395265 NM_001395266 NM_001395267 NM_001395268 NM_001395269 NM_001009978 NM_001009979 NM_001159582 NM_016744 NM_001355140 NM_001355141 NM_001355142 NM_001355143 NM_001355144 RefSeq (protein) NP_001003683 NP_001245241 NP_001245242 NP_001245243 NP_005010 NP_001350800 NP_001245241.1 NP_001009978 NP_001009979 NP_001153054 NP_058024 NP_001342069 NP_001342070 NP_001342071 NP_001342073 Location (UCSC) Chr 2: 182.14 – 182.52 Mb Chr 2: 79.66 – 79.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Snyder PB, Florio VA, Ferguson K, Loughney K (1999). "Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A)". Cell. Signal. 11 (7): 535–44. doi:10.1016/S0898-6568(99)00027-3. PMID 10405764.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Yan C, Zhao AZ, Sonnenburg WK, Beavo JA (2001). "Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis". Biol. Reprod. 64 (6): 1746–54. doi:10.1095/biolreprod64.6.1746. PMID 11369604.
• Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989.
• Ritter M, Buechler C, Boettcher A, et al. (2002). "Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I". Genomics. 79 (5): 693–702. doi:10.1006/geno.2002.6761. PMID 11991719.
• Lefièvre L, de Lamirande E, Gagnon C (2003). "Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa". Biol. Reprod. 67 (2): 423–30. doi:10.1095/biolreprod67.2.423. PMID 12135876.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Goraya TA, Masada N, Ciruela A, Cooper DM (2004). "Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A". J. Biol. Chem. 279 (39): 40494–504. doi:10.1074/jbc.M313441200. PMID 15272012.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nagel DJ, Aizawa T, Jeon KI, et al. (2006). "Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival". Circ. Res. 98 (6): 777–84. doi:10.1161/01.RES.0000215576.27615.fd. PMC 4114760. PMID 16514069.