Hypocretin (orexin) receptor 1

  (Redirected from Orexin receptor 1)

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene.[5]

HCRTR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHCRTR1, OX1R, Hypocretin (orexin) receptor 1, hypocretin receptor 1
External IDsOMIM: 602392 MGI: 2385650 HomoloGene: 37492 GeneCards: HCRTR1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HCRTR1
Genomic location for HCRTR1
Band1p35.2Start31,617,686 bp[1]
End31,632,518 bp[1]
RNA expression pattern
PBB GE HCRTR1 207619 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001525

NM_001163027
NM_198959
NM_001305392
NM_001357258

RefSeq (protein)

NP_001516

NP_001156499
NP_001292321
NP_945197
NP_001344187

Location (UCSC)Chr 1: 31.62 – 31.63 MbChr 4: 130.13 – 130.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FunctionEdit

The orexin 1 receptor (OX1), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.[5]

LigandsEdit

AgonistsEdit

AntagonistsEdit

See alsoEdit

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121764 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028778 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1".
  6. ^ "Eisai Demonstrates Efficacy of Investigational Dual Orexin Receptor Antagonist E2006 in Sleep Initiation and Maintenance Data from Phase II Clinical Trial for Insomnia".

External linksEdit

  • "Orexin Receptors: OX1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further readingEdit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.