OSCAR (gene)

Osteoclast-associated immunoglobulin-like receptor is a protein that in humans is encoded by the OSCAR gene.[5][6]

OSCAR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOSCAR, PIGR3, PIgR-3, osteoclast associated, immunoglobulin-like receptor, osteoclast associated Ig-like receptor
External IDsOMIM: 606862 MGI: 2179720 HomoloGene: 77042 GeneCards: OSCAR
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for OSCAR
Genomic location for OSCAR
Band19q13.42Start54,094,668 bp[1]
End54,102,692 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001290377
NM_175632

RefSeq (protein)

NP_001277306
NP_783440

Location (UCSC)Chr 19: 54.09 – 54.1 MbChr 7: 3.61 – 3.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[6]

ReferencesEdit

  1. ^ a b c ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 GRCh38: Ensembl release 89: ENSG00000277088, ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054594 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kim N, Takami M, Rho J, Josien R, Choi Y (Jan 2002). "A novel member of the leukocyte receptor complex regulates osteoclast differentiation". J Exp Med. 195 (2): 201–9. doi:10.1084/jem.20011681. PMC 2193610. PMID 11805147.
  6. ^ a b "Entrez Gene: OSCAR osteoclast-associated receptor".

Further readingEdit