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Olfactomedin 1

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Olfactomedin 1, also known as noelin 1 or pancortin, is a protein that in humans is encoded by the OLFM1 gene.[5][6] The name noelin stands for "neuronal olfactomedin-related endoplasmic reticulum-localized 1".[7]

OLFM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOLFM1, AMY, NOE1, NOELIN1, OlfA, olfactomedin 1
External IDsOMIM: 605366 MGI: 1860437 HomoloGene: 8612 GeneCards: OLFM1
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for OLFM1
Genomic location for OLFM1
Band9q34.3Start135,075,422 bp[1]
End135,121,179 bp[1]
RNA expression pattern
PBB GE OLFM1 210924 at fs.png

PBB GE OLFM1 205591 at fs.png

PBB GE OLFM1 213131 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_058199
NM_001282611
NM_001282612
NM_006334
NM_014279

NM_001038612
NM_001038613
NM_001038614
NM_019498

RefSeq (protein)

NP_001269540
NP_001269541
NP_006325
NP_055094

NP_001033701
NP_001033702
NP_001033703
NP_062371

Location (UCSC)Chr 9: 135.08 – 135.12 MbChr 2: 28.19 – 28.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.[6]

CancerEdit

OLFM1 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[8] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[8]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130558 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026833 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yokoyama M, Nishi Y, Yoshii J, Okubo K, Matsubara K (May 1997). "Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles". DNA Res. 3 (5): 311–20. doi:10.1093/dnares/3.5.311. PMID 9039501.
  6. ^ a b "Entrez Gene: OLFM1 olfactomedin 1".
  7. ^ Anholt, Robert R. H. (2014). "Olfactomedin proteins: central players in development and disease". Frontiers in Cell and Developmental Biology. 2: 6. doi:10.3389/fcell.2014.00006. PMC 4206993. PMID 25364714.
  8. ^ a b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602.

Further readingEdit