SCG5

Neuroendocrine protein 7B2 is a protein that in humans is encoded by the SCG5 gene. The protein expressed by this gene is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 by blocking the aggregation of this protein, and is required for the production of an active PC2 enzyme. It is an intrinsically disordered protein that may also function as a chaperone for other aggregating secretory proteins in addition to proPC2 (Helwig et al. 2013). 7B2 has been identified in vertebrates and in invertebrates as low as flatworms (Protein ID: AIZ72728.1) and insects. It is also called Sgne1 and Secretogranin V. In C. elegans, it was originally called e7B2 and then renamed Seven B Two (gene name sbt-1). There is a Pfam entry for this protein: Secretogranin_V (PF05281).

SCG5
Identifiers
Aliases	SCG5, 7B2, P7B2, SGNE1, SgV, secretogranin V
External IDs	OMIM: 173120 MGI: 98289 HomoloGene: 37722 GeneCards: SCG5
Gene location (Human) Chr. Chromosome 15 (human) Band 15q13.3 Start 32,641,676 bp End 32,697,098 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 E4|2 57.45 cM Start 113,776,362 bp End 113,829,121 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans superior frontal gyrus prefrontal cortex Brodmann area 9 anterior pituitary cerebellar cortex hypothalamus cerebellar hemisphere nucleus accumbens hippocampus proper Top expressed in paraventricular nucleus of hypothalamus medial vestibular nucleus lateral geniculate nucleus medial dorsal nucleus medial geniculate nucleus dorsal tegmental nucleus pontine nuclei dorsomedial hypothalamic nucleus ventral tegmental area lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding enzyme inhibitor activity GTP binding protein binding Cellular component extracellular region secretory granule Biological process regulation of hormone secretion intracellular protein transport neuropeptide signaling pathway peptide hormone processing negative regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6447 20394 Ensembl ENSG00000277614 ENSG00000166922 ENSG00000281931 ENSMUSG00000023236 UniProt P05408 P12961 RefSeq (mRNA) NM_001144757 NM_003020 NM_001394278 NM_001394279 NM_009162 RefSeq (protein) NP_001138229 NP_003011 NP_033188 Location (UCSC) Chr 15: 32.64 – 32.7 Mb Chr 2: 113.78 – 113.83 Mb PubMed search
Wikidata
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Further reading

• Mbikay M, Seidah NG, Chrétien M (July 2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions". The Biochemical Journal. 357 (Pt 2): 329–42. doi:10.1042/0264-6021:3570329. PMC 1221959. PMID 11439082.
• Paquet L, Lazure C, Seidah NG, Chrétien M, Mbikay M (January 1991). "The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man". Biochemical and Biophysical Research Communications. 174 (1): 156–62. doi:10.1016/0006-291X(91)90499-W. PMID 1989596.
• Roebroek AJ, Dehaen MR, van Bokhoven A, Martens GJ, Marÿnen P, van den Berghe H, Van de Ven WJ (1989). "Regional mapping of the human gene encoding the novel pituitary polypeptide 7B2 to chromosome 15q13----q14 by in situ hybridization". Cytogenetics and Cell Genetics. 50 (2–3): 158–60. doi:10.1159/000132749. PMID 2776483.
• Benjannet S, Marcinkiewicz M, Falgueyret JP, Johnson DE, Seidah NG, Chrétien M (August 1988). "Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors". Endocrinology. 123 (2): 874–84. doi:10.1210/endo-123-2-874. PMID 2840270.
• Martens GJ (July 1988). "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2". FEBS Letters. 234 (1): 160–4. doi:10.1016/0014-5793(88)81324-3. PMID 3134253.
• Brayton KA, Aimi J, Qiu H, Yazdanparast R, Ghatei MA, Polak JM, et al. (December 1988). "Cloning, characterization, and sequence of a porcine cDNA encoding a secreted neuronal and endocrine protein". DNA. 7 (10): 713–9. doi:10.1089/dna.1988.7.713. PMID 3234177.
• Marcinkiewicz M, Benjannet S, Falgueyret JP, Seidah NG, Schürch W, Verdy M, et al. (August 1988). "Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma". Endocrinology. 123 (2): 866–73. doi:10.1210/endo-123-2-866. PMID 3293987.
• Marcinkiewicz M, Benjannet S, Cantin M, Seidah NG, Chrétien M (August 1986). "CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles". Brain Research. 380 (2): 349–56. doi:10.1016/0006-8993(86)90233-7. PMID 3530373. S2CID 22326257.
• Seidah NG, Hsi KL, De Serres G, Rochemont J, Hamelin J, Antakly T, et al. (September 1983). "Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus". Archives of Biochemistry and Biophysics. 225 (2): 525–34. doi:10.1016/0003-9861(83)90063-2. PMID 6625600.
• Benjannet S, Savaria D, Chrétien M, Seidah NG (May 1995). "7B2 is a specific intracellular binding protein of the prohormone convertase PC2". Journal of Neurochemistry. 64 (5): 2303–11. doi:10.1046/j.1471-4159.1995.64052303.x. PMID 7722516. S2CID 7133644.
• Braks JA, Martens GJ (July 1994). "7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway". Cell. 78 (2): 263–73. doi:10.1016/0092-8674(94)90296-8. PMID 7913882. S2CID 24734254.
• Braks JA, Broers CA, Danger JM, Martens GJ (February 1996). "Structural organization of the gene encoding the neuroendocrine chaperone 7B2". European Journal of Biochemistry. 236 (1): 60–7. doi:10.1111/j.1432-1033.1996.00060.x. PMID 8617287.
• Bourdeau I, Antonini SR, Lacroix A, Kirschner LS, Matyakhina L, Lorang D, et al. (February 2004). "Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators". Oncogene. 23 (8): 1575–85. doi:10.1038/sj.onc.1207277. PMID 14767469. S2CID 25336472.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Dasgupta I, Sanglas L, Enghild JJ, Lindberg I (September 2012). "The neuroendocrine protein 7B2 is intrinsically disordered". Biochemistry. 51 (38): 7456–64. doi:10.1021/bi300871k. PMC 3457758. PMID 22947085.
• Helwig M, Hoshino A, Berridge C, Lee SN, Lorenzen N, Otzen DE, et al. (January 2013). "The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins". The Journal of Biological Chemistry. 288 (2): 1114–24. doi:10.1074/jbc.M112.417071. PMC 3542996. PMID 23172224.