National Marrow Donor Program

The National Marrow Donor Program (NMDP) is a nonprofit organization founded in 1986 and based in Minneapolis, Minnesota that operates the Be The Match Registry of volunteer hematopoietic cell donors and umbilical cord blood units in the United States.

National Marrow Donor Program
IndustryHealth care
FoundedSt. Paul, Minnesota, USA (1986)
HeadquartersMinneapolis, Minnesota, USA
Key people
Amy L. Ronneberg
Acting CEO
Chief Financial Officer
President, Be The Match BioTherapies
Number of employees
996 (October 2019)

The Be The Match Registry is the world's largest hematopoietic cell registry, listing nearly 16 million individuals and nearly 238,000 cord blood units. Hematopoietic cells from NMDP donors or cord blood units are used to transplant patients with a variety of blood, bone marrow or immune system disorders. As of September 2016, the NMDP had facilitated more than 80,000 transplants worldwide.


The NMDP coordinates the collection of hematopoietic ("blood-forming") cells that are used to perform what used to be called bone marrow transplants, but are now more properly called hematopoietic cell transplants. Patients needing a hematopoietic cell transplant but who lack a suitably matched donor in their family can search the Be The Match Registry for a matched unrelated donor or cord blood unit.[1]

Hematopoietic cells are used to transplant patients with life-threatening disorders such as leukemia, lymphoma, aplastic anemia, as well as certain immune system and metabolic disorders. Hematopoietic cells can come from bone marrow, umbilical cord blood, or the circulating blood (peripheral blood stem cells (PBSCs)). Hematopoietic cells are a type of adult (i.e., non-embryonic) stem cell that can multiply and differentiate into the three types of blood cells: red blood cells, white blood cells, and platelets.

Cheek swab being obtained from a potential donor

Collecting hematopoietic cellsEdit

Bone marrow and PBSCs come from living adult donors. Bone marrow is extracted from the donor's pelvic bones while the donor is under general or local anesthesia. PBSCs are collected from the donor's blood after five or six days of taking a drug that causes hematopoietic cells in the bone marrow to move into the circulating blood. In both cases, recovery is usually swift and donors typically have fully restored marrow and blood cell counts in under two weeks.

Cord blood cells are obtained from the umbilical cord and placenta of a newborn baby after the cord is clamped and cut as in a normal delivery. The cord blood is then stored frozen in a bank until needed for a transplant. The baby is not harmed in any way by this collection, as the cord blood is collected from tissues that in the past had been discarded as medical waste.

The need for large registriesEdit

The Be The Match registry is one of many registries of unrelated donors and cord blood units in the world. Most large, developed nations have such registries.[2] Large registries of unrelated donors are needed because only about 30% of patients with diseases treatable with hematopoietic cell transplantation can find a fully HLA matched donor among their family members.[3]

The remaining 70% require an unrelated hematopoietic cell donor as a transplant source.[4] Because the odds that two random individuals are HLA matched exceeds one in 20,000, a registry's success depends on a large number of volunteer donors.

Method of operationEdit

The NMDP coordinates hematopoietic cell transplants by managing a worldwide network of affiliated organizations. These organizations (mostly hospitals and blood banks) have established relationships with the NMDP and work together to arrange the collection and transfer of donated bone marrow or PBSCs, or the transfer of previously collected cord blood.

When an adult volunteer donor (marrow or PBSC) registers with the NMDP, their HLA and contact information is sent to the NMDP, which stores it in their computers. The NMDP also has nearly 238,000 cord blood units, listed by HLA type, in its Be The Match registry. These cord blood units are stored at 19 NMDP-affiliated cord blood banks around the world.

Physicians look for donor material on behalf of a patient by submitting the patient's HLA tissue type to the NMDP, which then searches its computerized database for matching donor (marrow or PBSC) or cord blood units.

If the NMDP finds a match with an adult donor, they notify the donor. After educating the potential donor about the donation process, the NMDP asks them to donate. If the potential donor wishes to proceed, they receive a medical exam, which includes testing the blood for infectious diseases. If the potential donor meets all requirements, the NMDP collects their bone marrow or peripheral blood stem cells and sends them by courier to the patient.

If the NMDP finds a match to a cord blood unit, they notify the cord blood bank that stores that unit and arrange to send it to the patient. Cord blood units are shipped frozen, in specially designed coolers, and are thawed after arrival at the patient's hospital. The transplant physician evaluating the patient considers a number of clinical factors to decide whether to use an adult donor's marrow or PBSC, or cord blood for a particular patient.

International connectionsEdit

The NMDP cooperates with Bone Marrow Donors Worldwide (BMDW), an organization that coordinates communications among the world's registries.[5] BMDW is based in Leiden, The Netherlands. Throughout the world, there are an estimated 30 million volunteer hematopoietic cell donors. Most national registries, including the NMDP's Be The Match registry, have access to these worldwide volunteer donors, either through the BMDW or through individually arranged agreements.

Although based in the United States, the NMDP has worldwide connections. More than 50 percent of the transplants arranged by the NMDP involve either a foreign patient or a foreign donor. The NMDP contracts with seven donor centers (where donors are recruited) outside of the United States. These are located in The Netherlands, Israel, Sweden, Norway, and Germany (three centers).[6]

In addition, the NMDP is affiliated with many transplant centers (where patients can receive transplants using cells from NMDP donors) outside of the United States.

Other United States registriesEdit

Although the NMDP operates the sole federally funded and Congressionally authorized stem cell registry in the United States, another domestic registry exists.[7]

  • The Gift of Life Marrow Registry, based in Boca Raton, Florida, was established in 1991 as a recruitment organization increasing ethnic diversity by enrolling donors of Jewish ancestry during the grassroots groundbreaking drives for New Jersey patient Jay Feinberg.[8][9] Now serving the broader community, its registry includes over 370,000 volunteer donors, resulting in over 17,000 matches and over 3,600 transplants[10]. Gift of Life is accredited by the World Marrow Donor Association.[11]
  • DKMS US, in New York City is part of the larger DKMS donor center based in Germany and hosts donor drives nationwide and lists those who register on the Be The Match registry, run by the NMDP.

In May 2004, the Gift of Life Marrow Registry and the NMDP formed an associate donor registry partnership.[11]

In July 2007, the Caitlin Raymond International Registry became an affiliated registry with the NMDP. Caitlin Raymond closed its doors a few years later.


The NMDP receives annually about US$23 million from the US government through the Health Resources and Services Administration. The US Navy also provides some funding.[12]

The program also receives income from donations, from monetary donations from tissue donors for tissue typing (about $50 as of 2008), from fees charged for in-depth database searches (initial searches are free, full searches can cost several thousand dollars), and from the fees charged to the transplanting hospital once a match is found and the stem cells have been transferred. The latter charge amounts to about $21,000, which is somewhat more than other registries in the US and abroad charge.[13] (The final cost to the patient or his/her insurance company for the completed transplant can range from $100,000 to $250,000.[14])

The NMDP pays affiliated donor centers and recruitment groups for every new donor they sign up.[13]

See alsoEdit


  1. ^ "Pre-Transplant Phase_Riley Hospital for Children" (PDF).
  2. ^ "Past, present and future of the National Marrow Donor Program" (PDF).
  3. ^ "Donating Bone Marrow Is Easy and Important: Here's Why". Cancer.Net. 2017-01-05. Retrieved 2019-11-20.
  4. ^ Dehn, Jason; Spellman, Stephen; Hurley, Carolyn K.; Shaw, Bronwen E.; Barker, Juliet N.; Burns, Linda J.; Confer, Dennis L.; Eapen, Mary; Fernandez-Vina, Marcelo; Hartzman, Robert; Maiers, Martin (2019-09-19). "Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR". Blood. 134 (12): 924–934. doi:10.1182/blood.2019001212. ISSN 0006-4971. PMC 6753623. PMID 31292117.
  5. ^ "D. Confer and P. Robinett: The US National Marrow Donor Program" (PDF).
  6. ^ Hayat, M.A. (2012). Stem Cells and Cancer Stem Cells (Vol. 8). p. 330.
  7. ^ [1] All registry and cord blood figures obtained from the Bone Marrow Donors Worldwide Web site, accessed 25 January 2007.
  8. ^ "Cancer battle spurs entrepreneur to start donor registry". Reuters. 2011-07-13. Retrieved 2019-11-20.
  9. ^ Stone, Judy. "What You Need To Know On World Bone Marrow Day". Forbes. Retrieved 2019-11-20.
  10. ^ Retrieved 2020-06-30
  11. ^ a b "Hillel of Syracuse University sponsoring Gift of Life Bone Marrow Registration Drive". SU News. Retrieved 2019-11-20.
  12. ^ Information on the National Bone Marrow Donor Registry Assessment, 2004, from Accessed 21 November 2006.
  13. ^ a b Bone Marrow Transplants--Despite Recruitment Successes, National Program May Be Underutilized, report by the GAO, October 2002
  14. ^ Bone Marrow/Stem Cell Transplants (BMT), from Ped-Onc Resource Center. Accessed 21 November 2006

External linksEdit