NELL1

Protein kinase C-binding protein NELL1 also known as NEL-like protein 1 (NELL1) or Nel-related protein 1 (NRP1) is a protein that in humans is encoded by the NELL1 gene.

NELL1
Identifiers
Aliases	NELL1, IDH3GL, NRP1, neural EGFL like 1
External IDs	OMIM: 602319 MGI: 2443902 HomoloGene: 4486 GeneCards: NELL1
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.1 Start 20,669,551 bp End 21,575,686 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B4 Start 49,624,612 bp End 50,516,356 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell orbitofrontal cortex Brodmann area 46 middle temporal gyrus prefrontal cortex sperm Brodmann area 10 superior frontal gyrus dorsolateral prefrontal cortex frontal pole Top expressed in medial geniculate nucleus medial dorsal nucleus lateral geniculate nucleus dorsomedial hypothalamic nucleus facial motor nucleus suprachiasmatic nucleus superior colliculus ventral tegmental area paraventricular nucleus of hypothalamus lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding protein kinase C binding heparin binding Cellular component cytoplasm perinuclear region of cytoplasm extracellular region nuclear envelope nucleus Biological process regulation of gene expression negative regulation of osteoblast proliferation cell differentiation positive regulation of osteoblast differentiation nervous system development positive regulation of bone mineralization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4745 338352 Ensembl ENSG00000165973 ENSMUSG00000055409 UniProt Q92832 Q2VWQ2 RefSeq (mRNA) NM_001288713 NM_001288714 NM_006157 NM_201551 NM_001037906 NM_177413 RefSeq (protein) NP_001275642 NP_001275643 NP_006148 NP_963845 NP_001032995 Location (UCSC) Chr 11: 20.67 – 21.58 Mb Chr 7: 49.62 – 50.52 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full-length sequence has not been determined.

Recent study by UCLA researchers shows that administering the protein NELL-1 intravenously stimulates significant bone formation through the regenerative ability of stem cells.

Further reading

• Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
• Ting K, Vastardis H, Mulliken JB, et al. (1999). "Human NELL-1 expressed in unilateral coronal synostosis". J. Bone Miner. Res. 14 (1): 80–9. doi:10.1359/jbmr.1999.14.1.80. PMID 9893069. S2CID 25664089.
• Luce MJ, Burrows PD (1999). "The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage". Gene. 231 (1–2): 121–6. doi:10.1016/S0378-1119(99)00093-1. PMID 10231576.
• Kuroda S, Oyasu M, Kawakami M, et al. (1999). "Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2". Biochem. Biophys. Res. Commun. 265 (1): 79–86. doi:10.1006/bbrc.1999.1638. PMID 10548494.
• Maeda K, Matsuhashi S, Tabuchi K, et al. (2002). "Brain specific human genes, NELL1 and NELL2, are predominantly expressed in neuroblastoma and other embryonal neuroepithelial tumors". Neurol. Med. Chir. (Tokyo). 41 (12): 582–8, discussion 589. doi:10.2176/nmc.41.582. PMID 11803583.
• Zhang X, Kuroda S, Carpenter D, et al. (2002). "Craniosynostosis in transgenic mice overexpressing Nell-1". J. Clin. Invest. 110 (6): 861–70. doi:10.1172/JCI15375. PMC 151127. PMID 12235118.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Okamoto K, Matsuzaka Y, Yoshikawa Y, et al. (2004). "Identification of NAD+-dependent isocitrate dehydrogenase 3 gamma-like (IDH3GL) gene and its genetic polymorphisms". Gene. 323: 141–8. doi:10.1016/j.gene.2003.09.014. PMID 14659887.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Truong T, Zhang X, Pathmanathan D, et al. (2007). "Craniosynostosis-associated gene nell-1 is regulated by runx2". J. Bone Miner. Res. 22 (1): 7–18. doi:10.1359/jbmr.061012. PMID 17042739. S2CID 24485075.
• Jin Z, Mori Y, Yang J, et al. (2007). "Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma". Oncogene. 26 (43): 6332–40. doi:10.1038/sj.onc.1210461. PMID 17452981.